Regulation of abdominal aortic aneurysms by calpain/calpastatin systems
Project/Area Number |
24790784
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Showa University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 腹部大動脈瘤 / 血管新生 / 血管内皮細胞 / 癌 / 網膜症 / カルパイン / プロテアーゼ / 動脈硬化症 |
Outline of Final Research Achievements |
Calpain, an intracellular multi-functional protease, reportedly participates in the various disorders including cardiovascular diseases. We herein revealed that the calpain systems are over-activated in vascular endothelial cells in abdominal aortic aneurysm in mice. The mice lacking calpain activity specifically in vascular endothelial cells exhibited normalization of adventitial immatured neovessels, thereby suppressing progression of aneurysms. Similar normalization of neovessels was detectable in cancer transplantation models and retinopathy models in mice, and was due to the over-activation of JAK/STAT inflammatory signals. These data suggests that calpain inhibition is promising approach for targeting pathological angiogenesis and related diseases.
|
Report
(4 results)
Research Products
(25 results)
-
[Journal Article] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.2015
Author(s)
Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J.R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
-
Journal Title
Circ. Res.
Volume: 116
Issue: 7
Pages: 1170-1181
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.2014
Author(s)
Kigawa Y, Miyazaki T, Lei XF, Nakamachi T, Oguchi T, Kim-Kaneyama JR, Taniyama M, Tsunawaki S, Shioda S, Miyazaki A
-
Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 34
Issue: 11
Pages: 2413-2420
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
[Journal Article] Identification of Hic-5 as a novel regulatory factor for integrinαIIbβ3 activation and platelet aggregation in mice2012
Author(s)
Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, Shioda S, Miyazaki A
-
Journal Title
J Thromb Haemostat
Volume: 10(9)
Issue: 9
Pages: 1867-1874
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-