| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Calpain, an intracellular multi-functional protease, reportedly participates in the various disorders including cardiovascular diseases. We herein revealed that the calpain systems are over-activated in vascular endothelial cells in abdominal aortic aneurysm in mice. The mice lacking calpain activity specifically in vascular endothelial cells exhibited normalization of adventitial immatured neovessels, thereby suppressing progression of aneurysms. Similar normalization of neovessels was detectable in cancer transplantation models and retinopathy models in mice, and was due to the over-activation of JAK/STAT inflammatory signals. These data suggests that calpain inhibition is promising approach for targeting pathological angiogenesis and related diseases.
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