| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Serum total cholesterol level was 2-fold higher in Apoe-/-Nmu-/- mice in Apoe-/- mice by a high-fat diet (HFD) treatment. However, there were no differences between both mice in atherosclerosis progression by both en face and aortic valve section analysis. There were no differences between peritoneal macrophages in both mice in the uptake of ox-LDL or the inflammation induced by ox-LDL treatment.
Nmu-/- mice developed hepatic steatosis induced by HFD, but Apoe-/-Nmu-/- mice did not develop it but increased the number of lipid-laden macrophages. Our findings suggest that NMU has no effect on the development of atherosclerosis, but has significant roles in cholesterol metabolism and some inflammation reaction.
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