| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
In the lungs of chronic obstructive pulmonary disease (COPD), emphysema severity was associated with an increase in alveolar B cell and CD4 T cell infiltration whereas thickening of bronchiolar walls was associated with a decrease in total collagen and an increase in type I collagen rather than inflammatory cell infiltration. Furthermore, it was found that collagen subtypes could be quantitatively detected by quantification of forward and backward second harmonic generation (SHG) signals with multi-photon excitation microscopy, and microarray analysis showed that genes associated with TGF-beta signaling pathway were down-regulated in the thickened bronchiolar walls.
|
