Investigation on the nature of tissue remodeling in COPD lungs
| Project/Area Number |
24790795
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
SUZUKI Masaru 北海道大学, 大学病院, 助教 (10374290)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 呼吸器内科 / 慢性閉塞性肺疾患 |
|---|
| Research Abstract |
In the lungs of chronic obstructive pulmonary disease (COPD), emphysema severity was associated with an increase in alveolar B cell and CD4 T cell infiltration whereas thickening of bronchiolar walls was associated with a decrease in total collagen and an increase in type I collagen rather than inflammatory cell infiltration. Furthermore, it was found that collagen subtypes could be quantitatively detected by quantification of forward and backward second harmonic generation (SHG) signals with multi-photon excitation microscopy, and microarray analysis showed that genes associated with TGF-beta signaling pathway were down-regulated in the thickened bronchiolar walls.
|
Report
(3 results)
Research Products
(12 results)
