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Resistance mechanisms of novel ALK inhibitors

Research Project

Project/Area Number 24790798
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

SASAKI Takaaki  旭川医科大学, 医学部, 助教 (70516997)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsALK陽性肺癌 / アレクチニブ / 薬剤耐性 / 国際情報交換
Research Abstract

Mechanisms of resistance with novel ALK tyrosine kinase, alectinib were investigated. H3122, EML4-ALK positive lung cancer cell line were treated with alectinib and showed resistance. These cell lines showed EGFR phosphorylation and MET signaling activation.
Combination therapy with EGFR tyrosine kinase inhibitor or MET inhibitor were effective for the treatment of H3122 alectinib resistance mouse xenograft model.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] 肺がんのoncogene addiction: 分子標的治療とその耐性2012

    • Author(s)
      佐々木高明
    • Journal Title

      分子呼吸器病学

      Volume: 16 Pages: 77-80

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Intrinsic and acquired resistance mechanisms of alectinib in ALK rearranged cells2014

    • Author(s)
      Yukiko Hibino1, Sasaki Takaaki1, Yoshinori Minami1, Pasi A. Janne2, Yoshinobu Ohsaki1
    • Organizer
      2Dana-Farber Cancer Institute, Boston, MA AACR annual meeting 2014
    • Place of Presentation
      1Asahikawa Medical University, Asahikawa, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Intrinsic and Acquired Resistance mechanisms of Alectinib in ALK rearranged cells2014

    • Author(s)
      Yukiko Hibino
    • Organizer
      AACR 2014
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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