| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We analyzed respiration in unanesthetized rodents using EMG/EEG radiotelemetry system and whole body pletysmography to evaluate respiratory change during/after hypoxia, hypercapnia, and intermittent hypoxia in each sleep-wake state. Diaphragm EMG was detected in unanesthetized rats during sleep and wakefulness. Genioglossus EMG was also detected, but artifacts caused by chewing, swallowing was contaminated in unanesthetized condition. Therefore, the respiratory change in genioglossus was not able to be evaluated. On the other hands, respiration during wakefulness and sleep after administration of novel wake-promoting agent modafinil, which is expected to promote respiration, was evaluated. But the results of the present study were not consistent with our original hypothesis that modafinil enhances ventilation with promoted wakefulness. Unexpectedly, the results showed that modafinil suppressed ventilation in room air and hypercapnic responses.
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