Respiratory neuroplastisity- upper airway patency during sleep

• Project/Area Number: 24790803
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: Terada Jiro 千葉大学, 医学(系)研究科(研究院), 助教 (20400898)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 呼吸の神経可塑性 / long-term facilitation / 上気道 / 横隔膜 / Long-term facilitation / 国際情報交換

Outline of Final Research Achievements

We　analyzed　respiration in unanesthetized rodents using EMG/EEG radiotelemetry system and whole body pletysmography to evaluate respiratory change during/after hypoxia, hypercapnia, and intermittent hypoxia in each sleep-wake state. Diaphragm EMG was detected in unanesthetized rats during sleep and wakefulness. Genioglossus EMG was also detected, but artifacts caused by chewing, swallowing was contaminated in unanesthetized condition. Therefore, the respiratory change in genioglossus was not able to be evaluated. On the other hands, respiration during wakefulness and sleep after administration of novel wake-promoting agent modafinil, which is expected to promote respiration, was evaluated. But the results of the present study were not consistent with our original hypothesis that modafinil enhances ventilation with promoted wakefulness. Unexpectedly, the results showed that modafinil suppressed ventilation in room air and hypercapnic responses.

Research Products

• [Journal Article] High levels of indium exposure relate to progressive emphysematous changes: a 9-year longitudinal surveillance of indium workers. (2015)
  • Author(s): Amata A, Chonan T, Omae K, Nodera H, Terada J, Tatsumi K.
  • Journal Title: Thorax Volume: 70 Issue: 11 Pages: 1040-1046
  • DOI: 10.1136/thoraxjnl-2014-206380
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation using the impulse oscillation system in patients with pulmonary sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases (2015)
  • Author(s): Suzuki T, Tsushima K, Kawata N, Matsumura T, Matsuura Y, Ichimura Y, Terada J, Sakao S, Tada Y, Tanabe N, Tatsumi K.
  • Journal Title: official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders Volume: 32 Pages: 144-150
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vascular Repair by Tissue-Resident Endothelial Progenitor Cells in Endotoxin-Induced Lung Injury. (2015)
  • Author(s): Kawasaki T, Nishiwaki T, Sekine A, Nishimura R, Suda R, Urushibara T, Suzuki T, Takayanagi S, Terada J, Sakao S, Tatsumi K.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 53 Issue: 4 Pages: 500-12
  • DOI: 10.1165/rcmb.2014-0185oc
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Features of REM-related Sleep Disordered Breathing in the Japanese Population (2015)
  • Author(s): Sakao S, Sakurai T, Yahaba M, Sakurai Y, Terada J, Tanabe N, Tatsumi K.
  • Journal Title: Internal Medicine Volume: 54 Issue: 12 Pages: 1481-1487
  • DOI: 10.2169/internalmedicine.54.4248
  • NAID: 130005075945
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoxia-induced proliferation of tissue-resident endothelial progenitor cells in the lung. (2014)
  • Author(s): Nishimura R, Kawasaki T, Sekine A, Suda R, Urushibara T, Suzuki T, Takayanagi S, Terada J, Sakao S, Tatsumi K
  • Journal Title: Am J Physiol Lung Cell Mol Physiol. Volume: 15 Issue: 8 Pages: 746-758
  • DOI: 10.1152/ajplung.00243.2014
  • Peer Reviewed / Open Access
• [Journal Article] The effects of emphysema on airway disease: Correlations between multi-detector CT and pulmonary function tests in smokers. (2014)
  • Author(s): Yahaba M, Kawata N, Iesato K, Matsuura Y, Sugiura T, Kasai H, Sakurai Y, Terada J, Sakao S, Tada Y, Tanabe N, Tatsumi K
  • Journal Title: Eur J Radiol Volume: Epub ahead of print Issue: 6 Pages: 0-0
  • DOI: 10.1016/j.ejrad.2014.03.003
  • Peer Reviewed / Open Access
• [Journal Article] Thrombomodulin for acute exacerbations of idiopathic pulmonary fibrosis: A proof of concept study. (2014)
  • Author(s): Tsushima K, Yamaguchi K, Kono Y, YokoyamaT, Kubo K, Matsumura T, Ichimura Y, Abe M, Terada J, Tatsumi K
  • Journal Title: Pulm Pharmacol Ther Volume: 29 Issue: 2 Pages: 233-240
  • DOI: 10.1016/j.pupt.2014.04.008
  • Peer Reviewed / Open Access
• [Journal Article] The accuracy and uncertainty of a sheet-type portable monitor as a screening device to identify obstructive sleep apnea-hypopnea syndrome. (2014)
  • Author(s): Tsukahara M, Sakao S, Jujo T, Sakurai T, Terada J, Kunii R, Tanabe N, Tatsumi K
  • Journal Title: Intern Med Volume: 53 Pages: 1307-1313
  • NAID: 130004466369
  • Peer Reviewed / Open Access
• [Journal Article] Home-based pulmonary rehabilitation in patients with inoperable or residual chronic thoromboembolic pulmonary hypertension: A preliminary study. (2014)
  • Author(s): Inagaki T, Terada J, Tanabe N, Kawata N, Kasai H, Sugiura T, Shigeta A, Asano Y, Murata A, Tsushima K, Tada Y, Sakao S, Tatsumi K
  • Journal Title: Respir Investig Volume: 52 Issue: 6 Pages: 357-364
  • DOI: 10.1016/j.resinv.2014.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Perioperative management with upfront combination therapy in a patient exhibiting idiopathic pulmonary hypertension with central pulmonary thrombosis. (2014)
  • Author(s): Umezawa H, Terada J, Tanabe N, Sugiura T, Naito A, Nishikimi K, Sakao S, Kasahara Y, Yoshida Y, Tatsumi K.
  • Journal Title: Intern Med. Volume: Epub ahead of print Pages: 0-0
  • NAID: 130003392736
  • Peer Reviewed
• [Journal Article] Autoimmune hepatitis in a patient with pulmonary arterial hypertension treated with endothelin receptor antagonists. (2014)
  • Author(s): Naito A, Terada J, Tanabe N, Sugiura T, Sakao S, Kanda T, Yokosuka O, Tatsumi K.
  • Journal Title: Intern Med. Volume: Epub ahead of print Pages: 0-0
  • NAID: 130003392737
  • Peer Reviewed
• [Journal Article] Usefulness of low-dose methotrexate monotherapy for treating sarcoidosis. (2013)
  • Author(s): Isshiki T, Yamaguchi T, Yamada Y, Maemura K, Makita K, Takeshima H, Hirasawa Y, Yamaguchi Y, Hosoki K, Suzuki M, Kono C, Terada J, Tatsumi K.
  • Journal Title: Intern Med. Volume: 52(24) Pages: 2727-2732
  • NAID: 130003383749
  • Peer Reviewed
• [Journal Article] Respiratory bronchiolitis and lung carcinoma (2013)
  • Author(s): Yoshihito Yamada, Jiro Terada, Koichiro Tatsumi, Chiyoko Kono, Masataka Tanno, Tamiko Takemura, Tetsuo Yamaguchi
  • Journal Title: Respiratory Investigation Volume: in press
• [Presentation] パーキンソン病患者の睡眠呼吸障害と深部脳 刺激療法の長期効果について (2015)
  • Author(s): 櫻井由子, 寺田二郎, 内山智之, 樋口佳則, 山中義崇, 山田真子, 野村文夫, 佐伯直勝, 桑原聡, 巽浩一郎
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 千代田区 東京国際フォーラム
  • Year and Date: 2015-04-17
• [Presentation] 肺胞低換気症候群における CPAP治療により改善しない高炭酸ガス血症の検討 (2015)
  • Author(s): 川田奈緒子, 寺田二郎, 巽浩一郎
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 千代田区 東京国際フォーラム
  • Year and Date: 2015-04-17
• [Presentation] 特発性間質性肺炎急性増悪の予後予測因子としてのEndotoxin Activity Assayの有用性 (2015)
  • Author(s): 安部光洋, 津島健司, 松村琢磨, 石綿司, 平澤康孝, 松村茜弥, 伊狩潤, 寺田二郎, 坂尾誠一郎, 多田裕司, 田邉信宏, 巽浩一郎
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 千代田区 東京国際フォーラム
  • Year and Date: 2015-04-17
• [Presentation] 当院で経験したGood症候群合併胸腺腫の検討 (2015)
  • Author(s): 岩沢俊一郎, 栗本遼太, 今井千晶, 植原貴史, 堺田恵美子, 伊狩潤, 寺田二郎, 多田裕司, 巽浩一郎, 滝口裕一
  • Organizer: 第112回日本内科学会総会・講演会
  • Place of Presentation: 京都 京都市 国立京都国際会館
  • Year and Date: 2015-04-12
• [Presentation] 肺高血圧症に対するリハビリテーション (2014)
  • Author(s): 寺田二郎.
  • Organizer: 第24回日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2014-10-25 – 2014-10-26
  • Invited
• [Presentation] 慢性血栓塞栓性肺高血圧症に対する呼吸リハビリテーション (2014)
  • Author(s): 稲垣武, 寺田二郎, 田邉信宏, 川田奈緒子, 笠井大 杉浦寿彦, 重田文子, 坂尾誠一郎, 村田淳, 巽浩一郎
  • Organizer: 第２回日本肺高血圧症学会（JPHS）第３回日本肺循環学会（JPCS）合同学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03 – 2014-10-05
• [Presentation] The effect of pirfenidone with patients with idiopathic pulmonary fibrosis in one university hospital (2014)
  • Author(s): Ichimura Y, Tsushima K, Matsumura T, Yokota A, Terada J, Iesato K, Sakao S, Tada Y, Tanabe N, Tatsumi K
  • Organizer: European respiratory society, International Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] Features of REM-related sleep-disordered breathing in the Japanese population (2014)
  • Author(s): Sakao S, Sakurai T, Yahaba M, Sakurai Y, Terada J, Tanabe N, Tatsumi K
  • Organizer: American thoracic society
  • Place of Presentation: San Diego, U.S
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] 肺循環障害の診断から治療up-to-date：肺高血圧症患者における血漿pentrasin3値の検討 (2014)
  • Author(s): 内藤亮、重田文子、田邉信宏、漆原崇司、加藤史照、須田理香、笠井大、西村倫太郎、関根亜由美、重城喬行、杉浦寿彦、寺田二郎、坂尾誠一郎、笠原靖紀、巽浩一郎
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-24 – 2014-04-27
• [Book] 呼吸器疾患関連検査 「日常診療のための検査値のみかた」 (2015)
  • Author(s): 寺田二郎, 巽浩一郎
  • Total Pages: 7
  • Publisher: 中外医学社
• [Book] 睡眠時無呼吸症候群. 2014今日の治療指針. (2014)
  • Author(s): 寺田二郎
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] 最新肥満症学 (2014)
  • Author(s): 巽浩一郎, 坂尾誠一郎, 寺田二郎
  • Total Pages: 5
  • Publisher: 日本臨牀社