Research Project
Grant-in-Aid for Young Scientists (B)
This study is basic research that explore the biomarker and factors overcoming drug resistance to anti-EGFR monoclonal antibody cetuximab in lung cancer. We found that KREMEN1 gene was overexpressed and Wnt signaling pathway was highly activated in cetuximab resistant cells. Therefore the inhibition of Wnt signaling pathway can possibility overcome the acquired resistance for cetuximab. Moreover this results can be applicable for lung cancer that is inherently resistance for cetuximab.
All 2013 2012
All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)
Cancer Biology&Therapy
Volume: 13 Pages: 1-10