| Project/Area Number |
24790814
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
GOTO Hisatsugu 徳島大学, ヘルスバイオサイエンス研究部, 講師 (00437641)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肺癌 / 肺サーファクタント / サーファクタント蛋白 / 肺がん / 肺サーファクタント蛋白 |
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| Research Abstract |
Surfactant protein (SP)-A has immunoregulatry function in the lungs. In addition, SP-A is used as a marker of lung adenocarcinoma, suggesting that SP-A also plays role in lung cancer progression. We investigated the role of SP-A in lung cancer progression by introducing the SP-A gene into human lung adenocarcinoma cell lines. SP-A gene transduction suppressed the progression of tumor mice. Immunohistochemical analysis showed that the number of M1 anti-tumor tumor-associated macrophages (TAMs) was increased in the tumor tissue produced by SP-A-expressing cells. In addition, natural killer (NK) cells were also increased and activated in the SP-A-expressing tumor. Taking into account that SP-A did not directly activate NK cells, these results suggested that SP-A inhibited lung cancer progression by recruiting and activating NK cells via controlling the polarization of TAMs.
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