Immunoreguratory function of surfactant protein A in lung cancer progression
Project/Area Number |
24790814
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | The University of Tokushima |
Principal Investigator |
GOTO Hisatsugu 徳島大学, ヘルスバイオサイエンス研究部, 講師 (00437641)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 肺癌 / 肺サーファクタント / サーファクタント蛋白 / 肺がん / 肺サーファクタント蛋白 |
Research Abstract |
Surfactant protein (SP)-A has immunoregulatry function in the lungs. In addition, SP-A is used as a marker of lung adenocarcinoma, suggesting that SP-A also plays role in lung cancer progression. We investigated the role of SP-A in lung cancer progression by introducing the SP-A gene into human lung adenocarcinoma cell lines. SP-A gene transduction suppressed the progression of tumor mice. Immunohistochemical analysis showed that the number of M1 anti-tumor tumor-associated macrophages (TAMs) was increased in the tumor tissue produced by SP-A-expressing cells. In addition, natural killer (NK) cells were also increased and activated in the SP-A-expressing tumor. Taking into account that SP-A did not directly activate NK cells, these results suggested that SP-A inhibited lung cancer progression by recruiting and activating NK cells via controlling the polarization of TAMs.
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Report
(3 results)
Research Products
(20 results)
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[Presentation] Surfactant protein A suppresses lung cancer progression by regulating tumor-associated macrophage polarization.
Author(s)
Hisatsugu Goto, Atsushi Mitsuhashi, Takuya Kuramoto, Sho Tabata, Sawaka Yukishige, Masaki Hanibuchi, Soji Kakiuchi, Atsuro Saijo, Yoshinori Aono, Hisanori Uehara, Seiji Yano, Julie G. Ledford, Saburo Sone, and Yasuhiko Nishioka.
Organizer
American Thoracic Society 2013 Conference
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in nude mice via modulating host immune response
Author(s)
Atsushi Mitsuhashi, Hisatsugu Goto, Takuya Kuramoto, Sho Tabata, Sawaka Yukishige, Masaki Hanibuchi, Soji Kakiuchi, Atsuro Saijo, Yoshinori Aono, Hisanori Uehara, Seiji Yano, Julie G Ledford, Saburo Sone, Yasuhiko Nishioka
Organizer
18th Congress of the Asian Pacific Society of Respirology
Place of Presentation
パシフィコ横浜(神奈川県)
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[Book] 呼吸2012
Author(s)
後東 久嗣
Total Pages
11
Publisher
レスピレーション リサーチ ファンデーション
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