| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Acute lung injury (ALI) is a major cause of severe respiratory failure. The pathogenesis of ALI remains ill defined, and the treatment of ALI remains largely supportive. We showed that T cell pathways involving cytotoxic T lymphocyte antigen 4 (CTLA4) may modulate the inflammation in ALI. We demonstrated that rapamycin, an immunosuppressant which inhibits T cell activation and induces regulatory T cells, ameliorates inflammation in ALI. We also determined a mechanism of the specific pathways by which CTLA4 are activated in ALI. The potential therapeutic impact of manipulating T cell pathways involving CTLA4 in ALI merits further investigation.
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