The effect of chronic oxidative stress on non-genomic action of mineralocorticoid receptor in the CA1 region.
| Project/Area Number |
24790834
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | The University of Tokyo (2014)
Tokyo Women's Medical University (2012-2013) |
|---|
Principal Investigator |
MORI Fumiko 東京大学, 先端科学技術研究センター, 研究員 (80431857)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ミネラロコルチコイド受容体 / 非ゲノム作用 / 酸化ストレス / 慢性酸化ストレス / ミネラルコルチコイド受容体 / 血圧 / エピジェネティック修飾 / 核内受容体 / 脳内酸化ストレス |
|---|
| Outline of Final Research Achievements |
We made chronic oxidative stress model by uninephrectomy and high salt loading to SD rat. and we found that non-genomic action of mineralocortioid receptor was diminished by chronic oxidative stressin the CA1 region of hippocampus. Further we confirmed that oxidative stress did not decrease MR expression itself, but decrease membranous MR expression.
|
Report
(4 results)
Research Products
(13 results)
