| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Our study suggested that increased plasma aldosterone and local Racl activation in the kidneys cooperatively activates MR and strongly develops renal impairment in obesity-related diabetic model mice. Glucose stimulation activates Racl and MR in cultured mesangial cells. Since Racl inhibition completely suppresses MR activation by glucose, it is suggested that glucose activates MR via Rac1. Cultured medium of fat cells isolated from obese rat strongly stimulates aldosterone secretion of the cultured adrenal cortex cells, and it suggests the fat cell derived aldsterone releasing factor and its increase in obesity.
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