Research Project
Grant-in-Aid for Young Scientists (B)
Purpose of the study is to elucidate the mechanism of dysfunction of macrophage and HDL cholesterol in kidney disease-accelerated atherosclerosis. HDL isolated from kidney disease patients induced macrophage inflammation and abnormal lipid metabolism. Indoxyl sulfate also induced macrophage inflammation and abnormal lipid metabolism. Those results indicate that indoxyl sulfate may induce dysfunctions of macrophage and HDL, and the intervention to them will be an attractive therapeutic strategy for kidney disease-accelerated atherosclerosis.
All 2015 2014 2013 2012 Other
All Journal Article (7 results) (of which Peer Reviewed: 7 results, Open Access: 2 results) Presentation (12 results) Book (3 results)
PLoS One
Volume: 10 Issue: 4 Pages: e0122691-e0122691
10.1371/journal.pone.0122691
Internal Medicine
Volume: 54 Issue: 1 Pages: 55-58
10.2169/internalmedicine.54.3484
130004902998
Clin Exp Nephrol
Volume: in press Issue: 2 Pages: 251-254
10.1007/s10157-013-0857-x
Volume: in press
Kidney International
Volume: 85 Issue: 1 Pages: 214-215
10.1038/ki.2013.412
Biochem J
Volume: 456 Issue: 3 Pages: e1-e3
10.1042/bj20131282
J Am Coll Cardiol
Volume: 60 Pages: 2372-2379