Dysfunction of HDL and macrophages in kidney disease-accelerated atherosclerosis and the therapeutic strategy
Project/Area Number |
24790837
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Niigata University |
Principal Investigator |
YAMAMOTO Suguru 新潟大学, 医歯(薬)学総合研究科, 特任助教 (70444156)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 慢性腎臓病 / 動脈硬化 / 心血管病 / HDLコレステロール / マクロファージ / インドキシル硫酸 / 腎臓病 / 尿毒素物質 / 動脈硬化症 / AST-120 / HDL / cholesterol efflux / reactive oxygen species / CKD |
Outline of Final Research Achievements |
Purpose of the study is to elucidate the mechanism of dysfunction of macrophage and HDL cholesterol in kidney disease-accelerated atherosclerosis. HDL isolated from kidney disease patients induced macrophage inflammation and abnormal lipid metabolism. Indoxyl sulfate also induced macrophage inflammation and abnormal lipid metabolism. Those results indicate that indoxyl sulfate may induce dysfunctions of macrophage and HDL, and the intervention to them will be an attractive therapeutic strategy for kidney disease-accelerated atherosclerosis.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis2015
Author(s)
Miura S, Kagamu H, Sakai T, Nozaki K, Asakawa K, Moro H, Okajima M, Watanabe S, Yamamoto S, Iino N, Goto S, Kazama JJ, Yoshizawa H, Narita I.
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Journal Title
Internal Medicine
Volume: 54
Issue: 1
Pages: 55-58
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dysfunctional high-density lipoprotein in patients on chronic hemodialysis.2012
Author(s)
Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V.
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Journal Title
J Am Coll Cardiol
Volume: 60
Pages: 2372-2379
Related Report
Peer Reviewed
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[Presentation] Continuous Reduction of Protein-bound Uremic Toxins with Improved Oxidative Stress by Oral Charcoal Adsorbent in Maintenance Hemodialysis Patients; An Additional Blood Purification Therapy2014
Author(s)
Suguru Yamamoto, Kentaro Omori, Koji Matsuo, Yoshimitsu Takahashi, Kazuko Kawamura, Minako Wakasugi, Hiroki Maruyama, Hiroshi Watanabe, Toru Maruyama, Junichiro J. Kazama, Ichiei Narita
Organizer
Am Soc Nephrol
Place of Presentation
Philadelphia convention center, Philadelphia, PA, USA
Year and Date
2014-11-10
Related Report
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[Presentation] Protein-bound uremic toxins were decreased continuously by oral charcoal adsorbent, AST-120, in maintenance hemodialysis patients2014
Author(s)
Suguru Yamamoto, Kentaro Omori, Koji Matsuo, Yoshimitsu Takahashi, Kazuko Kawamura, Minako Wakasugi, Hiroki Maruyama, Hiroshi Watanabe, Toru Maruyama, Junichiro J. Kazama, Ichiei Narita
Organizer
The 14th Asian Pacific Congress of Nephrology
Place of Presentation
SHINAGAWA PRINCE HOTEL 10-30 Takanawa 4-chome, Minato-ku, Tokyo, 108-8611 Japan
Year and Date
2014-05-16
Related Report
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[Presentation] Oral activated charcoal adsorbent, AST-120, induced continuous reduction of protein-bound uremic toxins in maintenance hemodialysis patients. A randomized crossover trial
Author(s)
Suguru Yamamoto, Kentaro Omori, Koji Matsuo, Yoshimitsu Takahashi, Kazuko Kawamura, Minako Wakasugi, Hiroki Maruyama, Junichiro J. Kazama, and Ichiei Narita
Organizer
American Society of Nephrology
Place of Presentation
Atlanta, USA
Related Report
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[Book] 腎と透析2014
Author(s)
山本卓、成田一衛
Total Pages
4
Publisher
東京医学社
Related Report
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