Influence of L-lysine on uremic memory

• Project/Area Number: 24790844
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: MATSUI Isao 大阪大学, 医学(系)研究科(研究院), 助教 (60456986)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: Uremic memory / 腎不全 / 血管石灰化 / L-Lysine / Ｕｒｅｍｉｃ ｍｅｍｏｒｙ / 尿素 / カルバミル化 / リジン / 骨粗鬆症

Research Abstract

Vascular calcification is one of the life-threatening complications of chronic kidney disease. Dietary L-lysine prevented arterial calcification in adenine-induced uremic rats. Dietary L-lysine strongly suppressed plasma intact parathyroid hormone in adenine rats, and thereby supported a proper bone-vascular axis. Dietary L-lysine elevated plasma alanine, proline, arginine, and homoarginine but not lysine. Analyses in vitro demonstrated that alanine and proline inhibit apoptosis of cultured vascular smooth muscle cells, and that arginine and homoarginine attenuate mineral precipitations in a supersaturated calcium/phosphate solution. Dietary supplementation of L-lysine ameliorated VC by modifying several key pathways that exacerbate VC.

Research Products

• [Journal Article] Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats (2014)
  • Author(s): Shimomura A, Matsui I, Hamano T, Ishimoto T, Katou Y, Takehana K, Inoue K, Kusunoki Y, Mori D, Nakano C, Obi Y, Fujii N, Takabatake Y, Nakano T, Tsubakihara Y, Isaka Y, Rakugi H
  • Journal Title: J Am Soc Nephrol Volume: Mar 20(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats. (2014)
  • Author(s): Shimomura A, Matsui I, Hamano T, Ishimoto T, Katou Y, Takehana K, Inoue K, Kusunoki Y, Mori D, Nakano C, Obi Y, Fujii N, Takabatake Y, Nakano T, Tsubakihara Y, Isaka Y, Rakugi H.
  • Journal Title: J Am Soc Nephrol. Volume: E-pub
  • Peer Reviewed
• [Presentation] アミノ酸L-lysineはアデニンラットの血管石灰化を抑制する (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: Kidney Summit
  • Place of Presentation: 東京
  • Year and Date: 2013-12-21
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: American Society of Nephrology, Kidney Week 2013
  • Place of Presentation: Atlanta (USA)
• [Presentation] アミノ酸 L-lysineはアデニンラットの血管石灰化を抑制する (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: 第58回日本透析医学会学術集会・総会
  • Place of Presentation: 福岡
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: ERA-EDTA 50th congress
  • Place of Presentation: Istanbul (Turkey)
• [Presentation] アミノ酸L-lysineはアデニンラットの血管石灰化を抑制する (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: 第58回日本透析医学会学術集会・総会
  • Place of Presentation: 福岡
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: ERA-EDTA 50th congress
  • Place of Presentation: Istanbul(Turkey)
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2013)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: American Society of Nephrology, Kidney Week 2013
  • Place of Presentation: Atlanta(U.S.A.)
• [Presentation] L-lysineは adenine ratの血管石灰化を抑制する (2012)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: アミノ酸第31回腎と骨代謝研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-06
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2012)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: American Society of Nephrology, Kidney Week 2012
  • Place of Presentation: San Diego (USA)
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats ISN Nexus (2012)
  • Author(s): 松井功、下村明弘、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、楽木宏実、猪阪善隆:
  • Organizer: Bone and the Kidney 2012, International Society of Nephrology
  • Place of Presentation: Copenhagen (Denmark)
• [Presentation] アミノ酸 L-lysineはアデニンラットの血管石灰化を抑制する (2012)
  • Author(s): 下村明弘、松井功、濱野高行、井上和則、中野智香子、小尾佳嗣、楠康生、椿原美治、楽木宏実、猪阪善隆
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] アミノ酸L-LysineはAdenineラットの血管石灰化を抑制する (2012)
  • Author(s): 下村明弘・松井功・濱野高行・井上和則・小尾佳嗣・中野智香子・楠康生・高畠義嗣・楽木宏実・猪阪善隆
  • Organizer: 第55回 日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] アミノ酸L-lysineはadenine ratの血管石灰化を抑制する (2012)
  • Author(s): 下村明弘・松井功・濱野高行・井上和則・中野智香子・小尾佳嗣・楠康生・椿原美治・楽木宏美・猪阪善隆
  • Organizer: 第31回 腎と骨代謝研究会
  • Place of Presentation: 東京
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2012)
  • Author(s): Akihiro Shimomura, Isao Matsui, Takayuki Hamano, Kazunori Inoue, Yoshitsugu Obi, Chikako Nakano, Yasuo Kusunoki, Yoshiharu Tsubakihara, Hiromi Rakugi, Yoshitaka Isaka
  • Organizer: Kidney Week 2012, American Society of Nephrology
  • Place of Presentation: San Diego, USA
• [Presentation] L-lysine ameliorates vascular calcification in adenine-induced uremic rats (2012)
  • Author(s): Isao Matsui, Akihiro Shimomura, Takayuki Hamano, Kazunori Inoue, Yasuo Kusunoki, Chikako Nakano, Yoshitsugu Obi, Yoshitaka Isaka, Hiromi Rakugi
  • Organizer: ISN Nexus: Bone and the Kidney 2012, International Society of Nephrology
  • Place of Presentation: Copenhagen, Denmark
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/kid/index.html