| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Muscle atrophy is a significant consequence of CKD that increases a patient’s risk of mortality and decrease their QOL. In these patients, the circulation levels of FGF23 are significantly increased, but the relationship between FGF23 and muscle atrophy are not clear. In this study, we attempted to identify the causative factors responsible for the shedding of Klotho, and whether both FGF23 and Klotho induced muscle atrophy. As a results, we found that AGEs, an accumulated in patients with CKD, increases shedding of Klotho in kidney cells. Moreover, we demonstrated that both FGF23 and sKlotho inhibited differentiation of cultured skeletal muscle cells through down-regulation of insulin/IGF-1 signaling. These observations suggested a divergent role of FGF23 and sKlotho in the regulation of skeletal muscle differentiation and thereby muscle atrophy under the pathological conditioned in CKD patients.
|
