Dendrin is an indication of disease activity and progression in IgA nephropathy
Project/Area Number |
24790858
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | dendrin / ポドサイト / IgA腎症 / 慢性腎不全 / 慢性糸球体腎炎 |
Outline of Final Research Achievements |
IgA nephropathy (IgAN) is associated with a substantial risk of progression to end-stage renal failure. The progression of IgAN is associated with podocyte injury and that podocyte injury is related to proteinuria. The translocation of dendrin to the podocyte nucleus as well as strong cathepsin L staining were detected in the glomeruli of IgAN. The translocation of dendrin to the podocyte nuclei enhances podocyte apoptosis.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy.2013
Author(s)
Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y.
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Journal Title
Nephrology Dialysis Transplantation.
Volume: 28
Issue: 7
Pages: 1762-1772
DOI
Related Report
Peer Reviewed