Dendrin is an indication of disease activity and progression in IgA nephropathy

Research Project

Project/Area Number	24790858
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Kidney internal medicine
Research Institution	Juntendo University
Principal Investigator	KODAMA Fumiko 順天堂大学, 医学部, 助教 (60599893)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	dendrin / ポドサイト / IgA腎症 / 慢性腎不全 / 慢性糸球体腎炎
Outline of Final Research Achievements	IgA nephropathy (IgAN) is associated with a substantial risk of progression to end-stage renal failure. The progression of IgAN is associated with podocyte injury and that podocyte injury is related to proteinuria. The translocation of dendrin to the podocyte nucleus as well as strong cathepsin L staining were detected in the glomeruli of IgAN. The translocation of dendrin to the podocyte nuclei enhances podocyte apoptosis.