| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Aβ deposition begins from 8month in Tg2576 model mice, and from 3 month in TgCRND8 mice. Memory disturbance begins from 6 month in Tg2576 mice, and from 5 month in TgCRND8 mice. CSF Aβ42 decreased with aging. In TgTauP301L mice, tau deposition begins from 2 month, NFT begins at 8 month, and memory disturbance begins from 12 month. In TgαSYN mice, α-synuclein begin from 2 month, cytoplasmic inclusions begin from 7 month, and behavior disturbance was found from 10.5 month. With protein deposition oin brain, behavioral disturbance wsd induced in theses model mice.
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