Development of therapy of Alzheimer's disease using biomarker
| Project/Area Number |
24790869
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Hirosaki University |
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Principal Investigator |
WAKASAYA Yasuhito 弘前大学, 医学(系)研究科(研究院), 助教 (10598725)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アミロイド / タウ / シヌクレイン / アルツハイマー病 / レビー小体型認知症 / 学習障害 / Abeta / 神経科学 / 認知症 / バイオマーカー / 臨床神経学 |
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| Outline of Final Research Achievements |
Aβ deposition begins from 8month in Tg2576 model mice, and from 3 month in TgCRND8 mice. Memory disturbance begins from 6 month in Tg2576 mice, and from 5 month in TgCRND8 mice. CSF Aβ42 decreased with aging. In TgTauP301L mice, tau deposition begins from 2 month, NFT begins at 8 month, and memory disturbance begins from 12 month. In TgαSYN mice, α-synuclein begin from 2 month, cytoplasmic inclusions begin from 7 month, and behavior disturbance was found from 10.5 month. With protein deposition oin brain, behavioral disturbance wsd induced in theses model mice.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] Abeta oligomers and prion in lipid rafts2014
Author(s)
Kawarabayashi T, Nakata T, Wakasaya Y, Nakamura T, Nakahata N, Shoji M
Organizer
Alzheimer’s Association International Conference 2014
Place of Presentation
Copenhagen, Denmark
Year and Date
2014-07-12 – 2014-07-17
Related Report
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