| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
It is difficult to evaluate the activity of ion channel in the leg, especially sensory nerves which often disturbed mainly in the patients with polyneuropathy. The aim of this study is to establish the nerve excitability technique in the sensory nerve at the lower extremities and to provide information about membrane potentials and axonal ion channel function for neuropathy patients, especially diabetic polyneuropathy. We established the technique of nerve excitability test in sural nerve using by near nerve needles.
We also tested the patients with diabetic polyneuropathy using this technique and suggest the disfunction of ion channels in diabetic polyneuropathy. Our study suggests that the nerve excitability test with near nerve needles may be useful to evaluate the activity of ion channel at sensory nerve in lower extremities and helpful to clarify the mechanism of diabetic polyneuropathy.
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