| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
TAR DNA binding protein of 43 kDa (TDP-43) is a nuclear protein and plays an important role for onset of amyotrophic lateral sclerosis (ALS). TDP-43 has been reported to associate with some nuclear bodies: Cajal body, GEM body, and PML. Therefore,I studied association between TDP-43 and GEM body in ALS pathology. The number of GEM bodies decreased in spinal motor neurons with ALS than those with normal; the volume of GEM bodies was not different between spinal motor neurons with ALS and normals. Moreover, the number of GEM bodies was similar between spinal motor neurons with and without nuclear TDP-43. These results suggest that decreased number of GEM bodies may be caused by dysfunction of TDP-43 in ALS.
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