Analysis of association between GEM body and motor neuron death
Project/Area Number |
24790875
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Niigata University |
Principal Investigator |
YOKOSEKI Akio 新潟大学, 医歯(薬)学総合研究科, 特任准教授 (90515719)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | ALS / TDP-43 / GEM / SMN / spinal motor neuron / spinal cord |
Outline of Final Research Achievements |
TAR DNA binding protein of 43 kDa (TDP-43) is a nuclear protein and plays an important role for onset of amyotrophic lateral sclerosis (ALS). TDP-43 has been reported to associate with some nuclear bodies: Cajal body, GEM body, and PML. Therefore,I studied association between TDP-43 and GEM body in ALS pathology. The number of GEM bodies decreased in spinal motor neurons with ALS than those with normal; the volume of GEM bodies was not different between spinal motor neurons with ALS and normals. Moreover, the number of GEM bodies was similar between spinal motor neurons with and without nuclear TDP-43. These results suggest that decreased number of GEM bodies may be caused by dysfunction of TDP-43 in ALS.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Sporadic ALS with compound heterozygous mutation in the SQSTM1 gene.2013
Author(s)
Shimizu H, Toyoshima Y, Shiga A, Yokoseki A, Arakawa K, Sekine Y, Shimohata T, Ikeuchi T, Nishizawa M, Kakita A, Onodera O, Takahashi H
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Journal Title
Acta Neuropathol
Volume: 126
Issue: 3
Pages: 453-459
DOI
Related Report
Peer Reviewed
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[Journal Article] Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients.2013
Author(s)
Ozawa T, Tokunaga J, Arakawa M, Ishikawa A, Takeuchi R, Mezaki N, Miura T, Sakai N, Hokari M, Takeshima A, Utsumi K, Kondo T, Yokoseki A, Nishizawa M
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Journal Title
Journal of Neurology
Volume: 260
Issue: 8
Pages: 2073-2077
DOI
Related Report
Peer Reviewed
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