| Project/Area Number |
24790882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Osaka University |
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Principal Investigator |
OKAZAKI Shuhei 大阪大学, 医学部附属病院, 医員 (60623072)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 動脈硬化 / 超音波 / 炎症 / インターロイキン６ / 頸動脈内中膜複合体 / 遺伝子多型 / インターロイキン6 / 超音波プラーク輝度 / 炎症マーカー |
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| Research Abstract |
The purpose of this study was to explore the relationship between carotid intima-media thickness (IMT) progression, plaque echogenicity of carotid atheroma, inflammatory cytokines, polymorphisms of inflammatory cytokine genes, and future cardiovascular events in patients with vascular risk factors. We also examined the relationship between serum inflammatory cytokines and long-term carotid IMT progression. We could not find a significant association of IMT progression and polymorphisms of inflammatory cytokine genes with future stroke. Echolucent large plaques (>2.0mm) were associated with future cardiovascular events. Chronic elevation of serum IL-6 was associated with the long-term carotid IMT progression. Our results suggest that measurement of echolucency in large carotid plaques may improve the selection of patients at high risk for cardiovascular events; serum IL-6 could be used as a quantitative marker and a potential therapeutic target for accelerated atherosclerosis.
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