Investigation into the mechanism of the blood-nerve barrier disruption in chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy
| Project/Area Number |
24790886
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SHIMIZU Fumitaka 山口大学, 医学(系)研究科(研究院), 助教 (90535254)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 自己免疫性ニューロパチー / 血液神経関門 / 慢性炎症性脱髄性根ニューロパチー / 多巣性運動ニューロパチー / 自己免疫性末梢神経疾患 / 末梢神経障害 / 国際情報交換 / 多国籍 |
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| Outline of Final Research Achievements |
<Purpose> The aim of this project was to elucidate the severity and mechanism of breakdown of the blood-nerve barrier (BNB) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). <Methods> We evaluated the effects of sera obtained from patients with typical CIDP/atypical CIDP/MMN and control subjects on the expression of claudin-5 and transendothelial electrical resistance (TEER) value in human peripheral nerve microvascular endothelial cells (PnMECs). <Result> Sera obtained from the patients with typical CIDP/atypical CIDP/MMN decreased the amount of claudin-5 protein levels and TEER values in PnMECs. The autocrine secretion of VEGF in PnMECs induced by MMN sera and immunoglobulin G purified from MMN sera decreased the expression of claudin-5. <Conclusion> Sera from CIDP/MMN patients disrupt the BNB function. In MMN, the autocrine secretion of VEGF in PnMECs and autoantibodies against PnMECs may be responsible for the BNB disruption.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Blood-brain barrier destruction determines Fischer/Bickerstaff clinical phenotypes: an in vitro study2013
Author(s)
Kazuyuki Saito, Fumitaka Shimizu, Michiaki Koga, Yasuteru Sano, Ayako Tasaki, Masa-aki Abe, Hiroyo Haruki, Toshihiko Maeda, S. Suzuki, Susumu Kusunoki, Hidehiro Mizusawa, Takashi Kanda.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 84
Issue: 7
Pages: 756-765
DOI
Related Report
Peer Reviewed
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