Early diagnosis of Parkinson disease by measuring the volume of the olfactory bulb and tract
Project/Area Number |
24790897
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2013-2016) Jikei University School of Medicine (2012) |
Principal Investigator |
Sengoku Renpei 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40385331)
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Project Period (FY) |
2012-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | パーキンソン病 / Lewy小体病 / 嗅球嗅索 / MRI / 嗅覚検査 / 嗅球嗅索体積 / MIBG心筋シンチグラフィー / 嗅覚障害 / 嗅球 / 体積 / 頭部MRI / 体積自動測定 / パーキンソン症候群 / volumetry / 匂い検査 / 嗅球体積 / 匂いテスト |
Outline of Final Research Achievements |
This study aimed to examine whether the volume of the olfactory bulbs and tracts (OB & T) on MRI is useful for differentiating Parkinson's disease (PD) from PD-related disorders. All patients were evaluated using the odor stick identification test for Japanese (OSIT-J), cardiac MIBG scintigraphy, and brain MRI. OB & T areas on 1-mm-thick coronal images were measured and summed for volumes. OB & T volume was smaller in PD than in other PD-related disorders (p<0.05). The cut-off for detecting PD patients was OSIT-J score <8, heart/mediastinum ratio <1.6, and OB & T volume <270 mm3. In the group with OSIT-J score <8 and OB & T volume <270 mm3, the proportion of PD patients among all patients with PD-related disorders was 91%. The rate of probable PD gradually increased as OSIT-J score and OB & T volume decreased (p<0.001). A combined morphological and functional evaluation of OB or cardiovascular dysautonomia could be useful for further differential of PD and other PD-related disorders.
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Report
(6 results)
Research Products
(65 results)
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[Journal Article] Olfactory function combined with morphology distinguishes Parkinson's disease2015
Author(s)
Sengoku R, Matsushima S, Bono K, Sakuta K, Yamazaki M, Miyagawa S, Komatsu T, Mitusmura H, Kono Y, Kamiyama T, Ito K, Mochio S, Iguchi Y
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Journal Title
Parkinsonism and Related Disorders
Volume: 印刷中
Issue: 7
Pages: 771-777
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Rhinorrhea in Parkinson's disease: a consecutive multicenter study in Japan.2014
Author(s)
Kano O, Yoshioka M, Nagayama H, Hamada S, Maeda T, Hasegawa T, Kadowaki T, Sengoku R, Terashi H, Hatano T, Nomoto N, Inoue M, Shimura H, Takahashi T, Uchiyama T, Watanabe H, Kaneko S, Takahashi T, Baba Y, Kubo S; Young Japanese Expert Group for Parkinson's Disease and Movement Disorders: YJ-EXPANDS.
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Journal Title
Journal of Neurological Science
Volume: 343
Issue: 1-2
Pages: 88-90
DOI
Related Report
Peer Reviewed
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[Journal Article] Rhinorrhea and Olfactory Dysfunction in Parkinson’s disease: a Multicenter Study in Japan2014
Author(s)
Kano O, Yoshioka M, Nagayama H, Hasegawa T, Kadowaki T, Hatano T, Shimura H, Maeda T, Sengoku R, Nomoto N, Takahashi T, Terashi H, Inoue M, Watanabe H, Baba Y, Kaneko S, Kubo S (Young Japanese Expert Group for Parkinson’s Disease and Movement)
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Journal Title
Journal of Neurological Science
Volume: ePub ahead
Related Report
Peer Reviewed
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[Presentation] Skin biopsy is useful for diagnostic tool of Lewy body disease2015
Author(s)
Sengoku R, Sumikura H, Saito Y, Nishina Y, Miyagawa S, Komatsu T, Ikemura M, Saito Y, Kanemaru K, Murayama S
Organizer
The MDS 19th International Congress of Parkinson's Disease and Movement Disorders
Place of Presentation
SanDiego, California, USA
Year and Date
2015-06-16
Related Report
Int'l Joint Research
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