| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study aimed to examine whether the volume of the olfactory bulbs and tracts (OB & T) on MRI is useful for differentiating Parkinson's disease (PD) from PD-related disorders. All patients were evaluated using the odor stick identification test for Japanese (OSIT-J), cardiac MIBG scintigraphy, and brain MRI. OB & T areas on 1-mm-thick coronal images were measured and summed for volumes. OB & T volume was smaller in PD than in other PD-related disorders (p<0.05). The cut-off for detecting PD patients was OSIT-J score <8, heart/mediastinum ratio <1.6, and OB & T volume <270 mm3. In the group with OSIT-J score <8 and OB & T volume <270 mm3, the proportion of PD patients among all patients with PD-related disorders was 91%. The rate of probable PD gradually increased as OSIT-J score and OB & T volume decreased (p<0.001). A combined morphological and functional evaluation of OB or cardiovascular dysautonomia could be useful for further differential of PD and other PD-related disorders.
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