Identification of the antibody induced by the new vaccine against Alzheimer's diseasese induces

Research Project

Project/Area Number	24790902
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurology
Research Institution	Tokyo Metropolitan Institute of Medical Science
Principal Investigator	NIIMI Naoko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (90405043)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	DNAワクチン / 抗体特異性 / アルツハイマー / アミロイドβ
Research Abstract	The molecular mechanisms of Alzheimer's disease remain unknown. A recent study suggested that amyloid oligomer not the senile plaques formed by Ab cause strong synaptic injyurious effects. In this study, we demonstrated that the anti-Ab oligomer antibody is potentiated and the Ab oligomer reduced by developing new DNA vaccines. This vaccines is worth examining in preclinical and clinical trials.

Report

(3 results)