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Mitochondrial dysfunction in familial Parkinson's disease.

Research Project

Project/Area Number 24790903
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research Institution防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工学群)

Principal Investigator

AMO Taku  防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工, 応用科学群, 助教 (40453922)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsパーキンソン病 / ミトコンドリア
Outline of Final Research Achievements

Mitochondrial dysfunction is a hallmark of both idiopathic and familial Parkinson's disease (PD). In this study, detailed analysis of mitochondrial dysfunction caused by loss of PINK1 revealed both of mitochondrial Complex I and III deficiencies. Recently, CHCHD2 was identified as a novel causative gene in mendelian forms of Parkinson’s disease. In this study, it was shown that CHCHD2 was localized in mitochondrial intermembrane space.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (13 results)

  • [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study.2015

    • Author(s)
      Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
    • Journal Title

      Lancet Neurol

      Volume: 14 Issue: 3 Pages: 274-282

    • DOI

      10.1016/s1474-4422(14)70266-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detailed analysis ofmitochondrial respiratory chain defects caused by loss of PINK1.2014

    • Author(s)
      Amo T, Saiki S, Sawayama T, Sato S, Hattori N.
    • Journal Title

      Neurosci Lett.

      Volume: 580 Pages: 37-40

    • DOI

      10.1016/j.neulet.2014.07.045

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.2013

    • Author(s)
      Sugiura, A., Nagashima, S., Tokuyama, T., Amo, T., Matsuki, Y., Ishido, S., Kudo, Y., McBride, H.M., Fukuda, T., Matsushita, T., Inatome, R., and C Yanagi, S.
    • Journal Title

      Mol. Cell

      Volume: 51 Issue: 1 Pages: 1-15

    • DOI

      10.1016/j.molcel.2013.04.023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A mitochondrial ubiquitin ligase MITOL regulates endoplasmic reticulum-mitochondria interaction via mitofusin22013

    • Author(s)
      A. Sugiura, S. Nagashima, T. Tokuyama, T. Amo, Y. Matsuki, S. Ishido, Y. Kudo, H. M. McBride, T. Fukuda, N. Matsushita, R. Inatome, S. Yanagi
    • Journal Title

      Molecular Cell

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 寒冷曝露下の鶏における骨格筋FNDC5/Irisin発現と脂肪組織avUCP発現の連関2015

    • Author(s)
      栗谷川あんな, 喜久里基, 白川仁, 天羽拓, 豊水正昭
    • Organizer
      第119回日本畜産学会大会
    • Place of Presentation
      宇都宮大学峰キャンパス(栃木県宇都宮市)
    • Year and Date
      2015-03-27 – 2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 常染色体優性遺伝性パーキンソン病の新規原因遺伝子単離2015

    • Author(s)
      舩山学, 大江賢治, 天羽拓, 古屋徳彦, 山口隼司, 斉木臣二, 李元哲, 大垣光太郎, 安藤真矢, 吉野浩代, 富山弘幸, 西岡健弥, 長谷川一子, 斎木英資, 佐竹渉, 茂櫛薫, 佐々木良元, 小久保康昌, 葛原茂樹, 戸田達史, 水野美邦, 内山安男, 大野欽司, 服部信孝
    • Organizer
      第49回日本運動障害研究会
    • Place of Presentation
      大日本住友製薬(株)東京本社(東京都中央区)
    • Year and Date
      2015-01-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗がん剤感受性を悪化させるミトコンドリアDNAのD-loop領域変異2014

    • Author(s)
      天羽拓, 宮本哲也, 上村尚美, 浅野弘匡, 麻生定光, 太田成男
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗がん剤感受性を悪化させるミトコンドリアDNAのD-loop領域変異2014

    • Author(s)
      天羽拓, 宮本哲也, 上村尚美, 浅野弘匡, 麻生定光, 太田成男
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] A somatic mutation of mitochondrial DNA confers resistance against an anti-cancer drug.2014

    • Author(s)
      Taku Amo, Tetsuya Miyamoto, Naomi Kamimura, Sadamitsu Asoh and Shigeo Ohta
    • Organizer
      9th International Meeting on Mitochondrial Pathology (Euromit2014)
    • Place of Presentation
      Tampere (Finland)
    • Year and Date
      2014-06-15 – 2014-06-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] PINK1,parkin過剰発現による細胞保護的なmitophagyの亢進がapoptosisを 誘導する2014

    • Author(s)
      河村美巴子,斉木臣二,古屋徳彦,今道洋子,天羽拓,矢野浩二郎, 服部信孝
    • Organizer
      第55 回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピロロキノリンキノン(PQQ)の添加が単離鶏ミトコンドリアの呼吸機能に及ぼす影響2014

    • Author(s)
      田邉拓也, 喜久里基, 天羽拓, 豊水正昭
    • Organizer
      日本畜産学会 第118回大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2013 Research-status Report
  • [Presentation] PINK1/parkin 過剰発現によるmitophagyとapoptosisの誘導作用について2013

    • Author(s)
      河村美巴子, 斉木臣二, 古屋徳彦, 今道洋子, 天羽拓, 矢野浩二朗, 服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Detailed analyses of mitochondrial respiratory chain defects caused by loss of PINK12013

    • Author(s)
      T. Amo, T. Sawayama, S. Sato, S. Saiki, A. M. Wolf, M. Toyomizu, T. Ichimura, C. A. Gautier, J. Shen, S. Ohta, N. Hattori
    • Organizer
      The 4th International Symposium on Dynamics of Mitochondria (DynaMito2013)
    • Place of Presentation
      沖縄残波岬ロイヤルホテル(沖縄県)
    • Related Report
      2013 Research-status Report
  • [Presentation] A somatic mutation of mitochondrial DNA confers resistance against an anti-cancer drug2013

    • Author(s)
      T. Amo, T. Miyamoto, N. Kamimura, S. Asoh, S. Ohta
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      六本木アカデミーヒルズ49(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 家族性パーキンソン病原因遺伝子PINK1欠損によるミトコンドリア膜電位低下は プロトンリークではなく呼吸鎖機能低下のためである2012

    • Author(s)
      天羽拓
    • Organizer
      認知症研究を知る若手研究者の集まり(主催:日本認知症学会)
    • Place of Presentation
      あいち健康プラザ(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Mitochondrial Membrane Potential Decrease Caused by Loss of Pink1 is not Due to Proton Leak, but to Respiratory Chain Defects2012

    • Author(s)
      T.Amo, S.Sato, S.Saiki, A.M.Wolf, M.Toyomizu, C.A.Gautier, J.Shen, S.Ohta, N.Hattori
    • Organizer
      European Bioenergetics Conference 2012
    • Place of Presentation
      University of Freiburg (Germany)
    • Related Report
      2012 Research-status Report
  • [Presentation] Excess of PINK1/parkin-mediated mitophagy induces apoptosis via various caspases activation2012

    • Author(s)
      M.Kawamura, S.Saiki, N.Furuya, Y.Imamichi, T.Amo, K.Yano, N.Hattori
    • Organizer
      6th International Symposium on Autophagy
    • Place of Presentation
      万国津梁館(沖縄県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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