Physiological analysis of SLC22A18 gene associated with visceral fat accumulation

Research Project

Project/Area Number	24790909
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Metabolomics
Research Institution	The University of Tokyo
Principal Investigator	YAMAMOTO Takashi 東京大学, 医学部附属病院, 特任助教 (00572033)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	メタボリックシンドローム / 連鎖解析 / 内臓脂肪 / トランスポーター
Research Abstract	In this study, to investigate the physiological functions of SLC22A18, an orphan transporter, in visceral fat accumulation and hepatic lipid accumulation, we analyzed SLC22A18-genetically modified mice and screened the endogenous substrate of SLC22A18. Animal experiments revealed that SLC22A18 positively regulates fat accumulation and triglyceride accumulation in liver. We found bilirubin as a candidate of SLC22A18 substrates. These results indicate the novel function of SLC22A18 and suggest the possibility of SLC22A18 as a therapeutic target of metabolic disorder.

Report

(3 results)