| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We have revealed the role of a co-chaperone, Sdf21, in a refed state in the liver. We further focused on interaction with BiP, a chaperone playing a pivotal role in endoplasmic reticulum (ER), which was elevated under endoplasmic reticulum (ER) stress in hepatocytes. In a mouse model of obesity and diabetes, however, expression of Sdf2l1 in the liver was down-regulated at the level of transcription, suggesting its pathophysiological importance via inability to respond to excessive ER stress. Actually ablation of Sdf2l1 in adult mice showed phenotypes similar to those in mice with the gene knocked down temporarily, which we analyzed before, adding further evidence to indicate the importance of hepatic Sdf2l1 in maintenance of systemic glucose and lipid homeostasis.
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