Research Project
Grant-in-Aid for Young Scientists (B)
The molecular mechanism of diabetic lipemia in the setting of insulin deficiency is not fully understood. We have previously found that the plasma level of triglycerides is lower in hormone-sensitive lipase (HSL) deficient mice than in wild-type mice when they are challenged with streptozotocin. The current study was aimed at elucidating the molecular mechanism of diabetic lipemia through the detailed analysis of HSL-deficient mice in the insulin-deficient status. We found that the enzymatic activity and mRNA levels of lipoprotein lipase (LPL) were not significantly different between wild-type and HSL-deficient mice in the insulin-deficient status. Other factors that regulate LPL activity in vivo or other pathways such as intestinal lipid absorption may explain the phenotypic difference, which are currently under investigation.
All 2014 2013
All Presentation (5 results)
