Pathophysiological role of adipo-hepatic axis in the development of non-alcoholic steatohepatitis
| Project/Area Number |
24790916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ITOH MICHIKO 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教員 (00581860)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メタボリックシンドローム / 慢性炎症 / マクロファージ / Crown-like structure / 肥満 / 脂肪組織 |
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| Research Abstract |
Obesity is now viewed as a state of systemic, chronic low-grade inflammation. There is considerable evidence that macrophages are infiltrated into obese adipose tissue to constitute crown-like structures, where they are aggregated to engulf dead adipocytes and induce inflammatory responses. We demonstrated the unique histological structure termed "hepatic crown-like structures" in the novel rodent model of human non-alcoholic steatohepatitis; melanocortin-receptor 4 deficient mice fed a Western diet. Our data provide evidence that hepatic crown-like structures are involved in the development of hepatic inflammation and fibrosis, thereby suggesting its pathophysiologic role in decease progression from simple steatosis to steatohepatitis.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Hepatic crown-like structure : a unique histological feature in non-alcoholic steatohepatitis in mice and humans2013
Author(s)
M. Itoh, H. Kato, T. Suganami, K. Konuma, Y. Marumoto, S. Terai, H. Sakugawa, S. Kanai, M. Hamaguchi, T. Fukaishi, S. Aoe, K. Akiyoshi, Y. Komohara, M. Takeya, I. Sakaida, Y. Ogawa
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Journal Title
PLoS ONE
Volume: 8
Issue: 12
Pages: e82163-e82163
DOI
Related Report
Peer Reviewed
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