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Pathophysiological role of adipo-hepatic axis in the development of non-alcoholic steatohepatitis

Research Project

Project/Area Number 24790916
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ITOH MICHIKO  東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教員 (00581860)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsメタボリックシンドローム / 慢性炎症 / マクロファージ / Crown-like structure / 肥満 / 脂肪組織
Research Abstract

Obesity is now viewed as a state of systemic, chronic low-grade inflammation. There is considerable evidence that macrophages are infiltrated into obese adipose tissue to constitute crown-like structures, where they are aggregated to engulf dead adipocytes and induce inflammatory responses. We demonstrated the unique histological structure termed "hepatic crown-like structures" in the novel rodent model of human non-alcoholic steatohepatitis; melanocortin-receptor 4 deficient mice fed a Western diet. Our data provide evidence that hepatic crown-like structures are involved in the development of hepatic inflammation and fibrosis, thereby suggesting its pathophysiologic role in decease progression from simple steatosis to steatohepatitis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (2 results) Remarks (7 results)

  • [Journal Article] Hepatic crown-like structure : a unique histological feature in non-alcoholic steatohepatitis in mice and humans2013

    • Author(s)
      M. Itoh, H. Kato, T. Suganami, K. Konuma, Y. Marumoto, S. Terai, H. Sakugawa, S. Kanai, M. Hamaguchi, T. Fukaishi, S. Aoe, K. Akiyoshi, Y. Komohara, M. Takeya, I. Sakaida, Y. Ogawa
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 12 Pages: e82163-e82163

    • DOI

      10.1371/journal.pone.0082163

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経系を介するレプチンの炎症・免疫調節作用2013

    • Author(s)
      伊藤美智子, 田中都, 菅波孝祥, 小川佳宏
    • Journal Title

      BIO Clinica

      Volume: 28 Pages: 45-48

    • Related Report
      2013 Final Research Report
  • [Journal Article] n-3多価不飽和脂肪酸と糖代謝改善, 動脈硬化改善のメカニズム2013

    • Author(s)
      伊藤美智子, 菅波孝祥, 小川佳宏
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 36 Pages: 502-506

    • Related Report
      2013 Final Research Report
  • [Journal Article] 脂肪酸の質的・量的変化がもたらす慢性炎症とメタボリックシンドローム2012

    • Author(s)
      伊藤美智子, 菅波孝祥, 小川佳宏
    • Journal Title

      実験医学

      Volume: 30 Pages: 418-422

    • Related Report
      2013 Final Research Report
  • [Presentation] NASH に対するEPA の予防・治療効果の検討-新規NASH モデルを用いて-(口演)2014

    • Author(s)
      小沼邦葉, 伊藤美智子, 他
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] NASH の病勢を反映する病理組織マーカー(口演) hepatic crown-like structure の意義2014

    • Author(s)
      伊藤美智子, 他
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-02-14
    • Related Report
      2013 Final Research Report
  • [Presentation] NASHの病勢を反映する病理組織マーカー:hepatic crown-like structureの意義2014

    • Author(s)
      伊藤美智子、菅波孝祥、小沼邦葉、丸本芳雄、寺井崇二、坂井田功、小川佳宏
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] NASH 発症におけるhepatic crown-like structure の意義(口演)2013

    • Author(s)
      伊藤美智子, 他
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] NASH発症におけるhepatic crown-like structureの意義2013

    • Author(s)
      伊藤美智子、菅波孝祥、小沼邦葉、丸本芳雄、寺井崇二、佐久川廣、坂井田功、小川佳宏
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Book] そうだったんだ!脂肪酸2012

    • Author(s)
      伊藤美智子, 他
    • Total Pages
      178
    • Publisher
      文光堂
    • Related Report
      2013 Final Research Report
  • [Book] 疾患モデルの作成と利用-糖尿病・肥満/感染症2012

    • Author(s)
      伊藤美智子, 他
    • Total Pages
      230
    • Publisher
      エル・アイ・シー
    • Related Report
      2013 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www.tmd.ac.jp/grad/cme/

    • Related Report
      2013 Final Research Report
  • [Remarks] プレスリリース 東京医科歯科大学 (2013/12/12)

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20131212.pdf

    • Related Report
      2013 Final Research Report
  • [Remarks] プレスリリース 山口大学(2013/12/20)

    • URL

      http://www.yamaguchi-u.ac.jp/topics/2013/_3094.html

    • Related Report
      2013 Final Research Report
  • [Remarks] プレスリリース 日本経済新聞(2013/12/12), 読売新聞(2013/1/9), 日刊工業新聞(2013/12/18)掲載

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京医科歯科大学大学院医歯学総合研究科 分子内分泌代謝学分野

    • URL

      http://www.tmd.ac.jp/grad/cme/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京医科歯科大学プレスリリース

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20131212.pdf

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京医科歯科大学大学院医歯学総合研究科 分子内分泌代謝学分野

    • URL

      http://www.tmd.ac.jp/grad/cme/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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