| Project/Area Number |
24790916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ITOH MICHIKO 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教員 (00581860)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メタボリックシンドローム / 慢性炎症 / マクロファージ / Crown-like structure / 肥満 / 脂肪組織 |
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| Research Abstract |
Obesity is now viewed as a state of systemic, chronic low-grade inflammation. There is considerable evidence that macrophages are infiltrated into obese adipose tissue to constitute crown-like structures, where they are aggregated to engulf dead adipocytes and induce inflammatory responses. We demonstrated the unique histological structure termed "hepatic crown-like structures" in the novel rodent model of human non-alcoholic steatohepatitis; melanocortin-receptor 4 deficient mice fed a Western diet. Our data provide evidence that hepatic crown-like structures are involved in the development of hepatic inflammation and fibrosis, thereby suggesting its pathophysiologic role in decease progression from simple steatosis to steatohepatitis.
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