Identification of novel energy metabolism-related genes by MASC assay
| Project/Area Number |
24790917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tokyo Medical and Dental University (2014)
Tokyo University of Science (2012-2013) |
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Principal Investigator |
FUJIKAWA Makoto 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90573048)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | エネルギー代謝制御 / 代謝学 / 生体エネルギー代謝 |
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| Outline of Final Research Achievements |
It is important for us to regulate accurately biological energy metabolism because of its demand for usual action, thermoregulation and so on. We developed and utilize a screening assay for novel energy metabolic regulators. As a result, it was discovered that the new factor is increased during deprivation of energy and activates the enzyme for energy production. In future, we aim to analyze how the new factor relate to the metabolic disorders which is such as diabetes in order to help prevent and cure those.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2013
Author(s)
Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
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Journal Title
PNAS
Volume: 111
Issue: 1
Pages: 273-278
DOI
Related Report
Peer Reviewed / Open Access
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