| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The transcriptional coactivator PGC-1alpha is implicated in the regulation of body mass and insulin sensitivity; however, its contribution to these conditions is unclear. Two recently identified PGC-1alpha variants are transcribed from an alternative promoter and induced by exercise in skeletal muscle. Here we show that mice lacking these variants develop age-dependent obesity and insulin resistance. Although the total PGC-1alpha abundance in skeletal muscle was unaltered under static conditions, exercise-induced increases in total PGC-1alpha and energy expenditure were attenuated in the mutant mice. These results suggest that PGC-1alpha variants are responsible for exercise-induced PGC-1alpha upregulation, which in turn plays an important role in controlling fat mass and insulin sensitivity via the regulation of energy expenditure during exercise.
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