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Development of novel PSGL-1 targeted agents for metabolic syndrome

Research Project

Project/Area Number 24790927
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionOkayama University

Principal Investigator

HORIGUCHI Chikage  岡山大学, 医学部, 客員研究員 (40535192)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsメタボリックシンドローム / PSGL-1 / 接着分子 / 内臓脂肪 / インスリン抵抗性 / 肥満 / フコイダン
Research Abstract

Anti-PSGL-1 antibodies inhibited adipocyte hypertrophy and inflammation in white adipose tissue, and then ameliorated insulin resistance in type 2 diabetic mice. We separated and purified Fucoidan as a type of sulfated polysaccharides according to molecular weight. We are studying inhibition effects of each purified substances by using of monocytes-to-endothelial cells adhesion assay in vitro. We are going to determine the most effective substances for inhibiting cell adhesion, and then administer them to type 2 diabetic mice and study insulin resistance.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (15 results) Book (2 results)

  • [Journal Article] Nuclear hormone receptor expression in mouse kidney and renal cell lines2014

    • Author(s)
      Ogawa D, Eguchi J, Wada J, Terami N, Hatanaka T, Tachibana H, Nakatsuka A, Horiguchi CS, Nishii N, Makino H
    • Journal Title

      PLoS ONE

      Volume: 9(1) Issue: 1 Pages: e85594-e85594

    • DOI

      10.1371/journal.pone.0085594

    • NAID

      120005723280

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice2014

    • Author(s)
      Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horiguchi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 306(1)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice.2014

    • Author(s)
      Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horiguchi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 1;306(1) Pages: 105-115

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO).2013

    • Author(s)
      Murakami K
    • Journal Title

      Diab Vasc Dis Res

      Volume: 10(1) Issue: 1 Pages: 93-96

    • DOI

      10.1177/1479164112444640

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice.2013

    • Author(s)
      Sato-Horiguchi C
    • Journal Title

      Nephron Exp Nephrol

      Volume: 121(3-4) Issue: 3-4 Pages: 97-108

    • DOI

      10.1159/000343102

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of emphysematous cholecystitis in a patient with type 2 diabetes mellitus associated with schizophrenia2012

    • Author(s)
      Ogawa A, Shikata K, Uchida HA, Shinoura S, Yokomichi N, Ogawa D, Sato-Horiguchi C, Yagi T, Wada J, Makino H
    • Journal Title

      J Diabetes Invest

      Volume: 3(6) Pages: 534-535

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy.2012

    • Author(s)
      Tachibana H
    • Journal Title

      J Am Soc Nephrol

      Volume: 23(11) Issue: 11 Pages: 1835-1846

    • DOI

      10.1681/asn.2012010022

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex2012

    • Author(s)
      Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
    • Journal Title

      Diabetes

      Volume: 61(11) Issue: 11 Pages: 2823-2832

    • DOI

      10.2337/db12-0232

    • NAID

      120005300245

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage : anti-inflammatory effect of cholecystokinin2012

    • Author(s)
      Miyamoto S, Shikata K, Miyasaka K, Okada S, Sasaki M, Kodera R, Hirota D, Kajitani N, Takatsuka T, Kataoka HU, Nishishita S, Sato C, Funakoshi A, Nishimori H, Uchida HA, Ogawa D, Makino H
    • Journal Title

      Diabetes

      Volume: 61(4) Issue: 4 Pages: 897-907

    • DOI

      10.2337/db11-0402

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病マウス腎および高糖濃度刺激下での培養腎細胞における核内受容体の発現解析2013

    • Author(s)
      寺見直人, 小川大輔, 堀口千景, 他
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本(熊本市現代美術館)
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 2型糖尿病における腎症の寛解および改善に関与する因子の解析2013

    • Author(s)
      小野哲一郎, 四方賢一, 堀口千景, 他
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本(熊本公徳会武道場)
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Liver X receptor agonist ameliorates diabetic nephropathy by inhibiting high glucose-induced osteopontin expression in proximal tubular epithelial cells2012

    • Author(s)
      Ogawa D, Tachibana H, Sato-Horiguchi C, et al
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 早期糖尿病性腎症におけるTelmisartan の抗酸化作用の検討2012

    • Author(s)
      堀口 千景, 他
    • Organizer
      第27回日本糖尿病合併症学会
    • Place of Presentation
      福岡(アクロス福岡)
    • Related Report
      2013 Final Research Report
  • [Presentation] Liver X receptor agonist ameliorates diabetic nephropathy by inhibiting high glucose-induced osteopontin expression in proximal tubular epithelial cells2012

    • Author(s)
      Ogawa D, Tachibana H, Sato-Horiguchi C, et al
    • Organizer
      ASN kidney Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibition of PSGL-1 ameliorates obesity-related insulin resistance by prevention of inflammation in adipose tissue and liver in db/db mice2012

    • Author(s)
      Daisho Hirota, Chikage Sato, et al
    • Organizer
      EASD 48th Annual Meeting
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] 早期糖尿病性腎症におけるTelmisartan の抗酸化作用の検討2012

    • Author(s)
      佐藤 千景, 他
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Final Research Report
  • [Presentation] PSGL-1 を阻害することにより, 肥満マウスにおける内臓脂肪と肝臓の炎症とインスリン抵抗性が抑制される2012

    • Author(s)
      廣田 大昌, 佐藤 千景, 他
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病性腎症モデルラットにおけるメタロチオネイン(metallothionein)の発現の検討2012

    • Author(s)
      橘 洋美, 佐藤 千景, 他
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Final Research Report
  • [Presentation] 早期糖尿病性腎症におけるTelmisartanの抗酸化作用の検討2012

    • Author(s)
      佐藤 千景
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] 早期糖尿病性腎症におけるTelmisartanの抗酸化作用の検討2012

    • Author(s)
      堀口 千景
    • Organizer
      第27回日本糖尿病合併症学会
    • Place of Presentation
      福岡(アクロス福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] PSGL-1を阻害することにより,肥満マウスにおける内臓脂肪と肝臓の炎症とインスリン抵抗性が抑制される2012

    • Author(s)
      廣田 大昌、佐藤 千景他
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] Inhibition of PSGL-1 ameliorates obesity-related insulin resistance by prevention of inflammation in adipose tissue and liver in db/db mice.2012

    • Author(s)
      Daisho Hirota, Chikage Sato, et al.
    • Organizer
      EASD 48th Annual Meeting
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Research-status Report
  • [Presentation] 2型糖尿病における腎症の寛解および改善に関与する因子の解析

    • Author(s)
      小野哲一郎、四方賢一、小比賀美香子、梶谷展生、小寺 亮、廣田大昌、村上和敏、堀口千景、小川大輔、和田 淳、片岡仁美、槇野博史
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本公徳会武道場(熊本県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病マウス腎および高糖濃度刺激下での培養腎細胞における核内受容体の発現解析

    • Author(s)
      寺見直人、小川大輔、橘 洋美、堀口千景、小寺 亮、江口 潤、中司敦子、和田 淳、四方賢一、槇野博史
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本市現代美術館(熊本県)
    • Related Report
      2013 Annual Research Report
  • [Book] 糖尿病×CKD 診療ガイド Q&A2012

    • Author(s)
      堀口 千景
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Book] 糖尿病×CKD 診療ガイド Q&A2012

    • Author(s)
      堀口 千景
    • Total Pages
      179
    • Publisher
      南山堂
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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