Development of novel PSGL-1 targeted agents for metabolic syndrome
| Project/Area Number |
24790927
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メタボリックシンドローム / PSGL-1 / 接着分子 / 内臓脂肪 / インスリン抵抗性 / 肥満 / フコイダン |
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| Research Abstract |
Anti-PSGL-1 antibodies inhibited adipocyte hypertrophy and inflammation in white adipose tissue, and then ameliorated insulin resistance in type 2 diabetic mice. We separated and purified Fucoidan as a type of sulfated polysaccharides according to molecular weight. We are studying inhibition effects of each purified substances by using of monocytes-to-endothelial cells adhesion assay in vitro. We are going to determine the most effective substances for inhibiting cell adhesion, and then administer them to type 2 diabetic mice and study insulin resistance.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice2014
Author(s)
Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horiguchi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H
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Journal Title
Am J Physiol Renal Physiol
Volume: 306(1)
Related Report
Peer Reviewed
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[Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice.2014
Author(s)
Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horiguchi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H.
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Journal Title
Am J Physiol Renal Physiol.
Volume: 1;306(1)
Pages: 105-115
Related Report
Peer Reviewed
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[Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex2012
Author(s)
Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
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Journal Title
Diabetes
Volume: 61(11)
Issue: 11
Pages: 2823-2832
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage : anti-inflammatory effect of cholecystokinin2012
Author(s)
Miyamoto S, Shikata K, Miyasaka K, Okada S, Sasaki M, Kodera R, Hirota D, Kajitani N, Takatsuka T, Kataoka HU, Nishishita S, Sato C, Funakoshi A, Nishimori H, Uchida HA, Ogawa D, Makino H
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Journal Title
Diabetes
Volume: 61(4)
Issue: 4
Pages: 897-907
DOI
Related Report
Peer Reviewed
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