Identification of the role of type 2 diabetes susceptible gene SLC30A8

• Project/Area Number: 24790933
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: The University of Tokushima (2014); Juntendo University (2012-2013)
• Principal Investigator: TAMAKI MOTOYUKI 徳島大学, 糖尿病臨床・研究開発センター, 助教 (60624400)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵β細胞 / インスリン / 糖尿病 / 亜鉛 / 亜鉛トランスポーター / 国内研究者交流

Outline of Final Research Achievements

We revealed the physiological expression site of SLC30A8, and expression levels of SLC30A8/ZnT8 was markedly decreased in diabetic model mice (Tamaki M. et al. Islets. 1(2); 124-128, 2009). We next generate pancreatic beta cell specific SLC30A8 knock out mice. These mice showed that loss of SLC30A8 was associated with not only beta cell dysfunction, but also worsening hepatic insulin clearance. We reported these findings in Journal of Clinical Investigation (Tamaki M. et al. J Clin Invest. 123(10); 4513-4524, 2013).

Research Products

• [Journal Article] Role of Zinc in Type 2 Diabetes (2014)
  • Author(s): Motoyuki Tamaki
  • Journal Title: Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) Volume: 69 Issue: 1 Pages: 15-23
  • DOI: 10.1265/jjh.69.15
  • NAID: 130003394510
  • ISSN: 0021-5082, 1882-6482
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance (2013)
  • Author(s): Tamaki, M., Fujitani, Y, Uchida, T., Tamura, Y., Takeno, K., Kawaguchi, M., Watanabe, T., Hara, A., Ogihara, T., Shimizu, T., Mita, T., Hirose, T., Ohara-Imaizumi, M., Abe, T., Kiyonari, H., Hojyo, S., Fukada, T., Nagamatsu, S., Hirano, T., Kawamori, R., Watada, H.
  • Journal Title: J Clin Invest Volume: 123 Issue: 10 Pages: 4513-4524
  • DOI: 10.1172/jci68807
  • Peer Reviewed
• [Presentation] 糖尿病発症・進展にかかわる新規メカニズムの解明 (2015)
  • Author(s): 田蒔基行
  • Organizer: 日本内分泌学会
  • Place of Presentation: ホテルニューオオタニ（東京都）
  • Year and Date: 2015-04-23 – 2015-04-25
  • Invited
• [Remarks] 亜鉛輸送担体ZｎT8の糖尿病発症における役割
• [Remarks] 糖尿病発症における亜鉛の役割を解明～肝臓でのインスリンの過剰な分解が糖尿病のリスクを高める～
• [Remarks] 順天堂大学大学院医学研究科代謝内分泌学
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/taisya_naibunpitsu/k4.html