Research of PI3Kinase and GLP-1 signal in pancreatic beta cells
| Project/Area Number |
24790939
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 糖尿病 / 膵β細胞 / インスリンシグナル / GLP-1シグナル / PI3K / GLP1 |
|---|
| Research Abstract |
GLP-1 is important for regulation of insulin secretion in pancreatic beta cells but the signaling of GLP-1 is not well known. We previously reported that inhibition of class IA phosphatidylinositol 3-kinase (PI3K), using a mouse model lacking the pik3r1 gene specifically in beta cells and the pik3r2 gene systemically (beta DKO mouse), results in glucose intolerance and reduced early insulin secretion. We investigated the relation of GLP-1 and PI3K. The administration of GLP-1 analog in beta DKO mice didn`t recover the early insulin secretion. The microarray analysis showed the down-regulation of lipid and mitochondria related genes and GLP1 receptor gene. This result indicated that PI3K in pancreatic beta cells is important for lipid and mitochondria homeostasis and regulate expression of GLP-1 receptor.
|
Report
(3 results)
Research Products
(19 results)
-
-
-
-
-
-
-
-
-
[Presentation] Weber-Christian 病を背景に全身性脂肪萎縮症を来たし, インスリン抵抗性を主体とした糖尿病と線維化を伴う脂肪肝を呈した一例2013
Author(s)
小田原 紗羅, 笹子 敬洋, 芥 直子, 諏訪内 浩紹, 杉森 祐介, 榎奥 健一郎, 松坂 恵介, 鈴木 亮, 山内 敏正, 植木 浩二郎, 門脇 孝
Organizer
第14回日本内分泌学会 関東甲信越支部学術学会
Year and Date
2013-09-28
Related Report
-
-
-
-
-
-
-
[Presentation] ヒト脂肪組織発現解析を用いた病態特異的アディポカインの検索2012
Author(s)
岡崎 由希子, 植木 浩二郎, 岩根 亜弥, 小林 直樹, 坂田 道教, 粟澤 元晴, 笹子 敬洋, 小林 正稔, 梅原 敏弘, 諏訪内 浩紹, 藤田 逸人, 堀越桃子, 大杉 満, 窪田 直人, 山内 敏正, 原 一雄, 吉村 浩太郎, 光嶋 勲, 油谷 浩幸, 門脇 孝
Organizer
第55回日本糖尿病学会年次学術集会
Year and Date
2012-05-19
Related Report
-
-
-
[Presentation] ヒト脂肪組織発現解析を用いた病態特異的アディポカインの検索2011
Author(s)
岡崎 由希子, 植木 浩二郎, 岩根 亜弥, 原 一雄, 粟澤 元晴, 金子 和真, 笹子 敬洋, 小林 直樹, 小林 正稔, 諏訪内 浩紹, 坂田 道教, 堀越 桃子, 大杉 満, 山内 敏正, 吉村 浩太郎, 光嶋 勲, 油谷 浩幸, 門脇 孝
Organizer
第54回日本糖尿病学会年次学術集会
Year and Date
2011-05-20
Related Report
