The study of regulatory mechanisms on ghrelin secretion
Project/Area Number |
24790941
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | Saitama University |
Principal Investigator |
SAKATA Ichiro 埼玉大学, 理工学研究科, 准教授 (80610831)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | グレリン / 交感神経 / GPRC5b / グレリン分泌 / 視床下部 / GPR120 |
Outline of Final Research Achievements |
In this study, it has found that these cells express high levels of mRNA encoding G-protein coupled receptor 120 (GPR120). Addition of GW9508 (a GPR120 chemical agonist) and α-linolenic acid (a natural ligand for GPR120) inhibited the secretion of ghrelin. However, the expression levels of preproghrelin and ghrelin O-acyltransferase (GOAT) mRNAs were not influenced by GW9508. Pretreatment with GW-9508 blocked the effect of the norepinephrine (NE)-induced ghrelin elevation in ghrelin cell lines, and GW-9508 inhibited ghrelin secretion via extracellular signal-regulated kinase activity in ghrelin cell lines. These results indicate that the decrease of ghrelin secretion after feeding is induced partially by long-chain fatty acids.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.2013
Author(s)
Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, Piper PK, Walker AK, Pedersen MH, Nohr MK, Pan J, Sinz CJ, Carrington PE, Akiyama TE, Jones RM, Tang C, Ahmed K, Offermanns S, Egerod KL, Zigman JM, Schwartz TW.
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Journal Title
Mol Metab
Volume: 4
Issue: 4
Pages: 376-392
DOI
Related Report
Peer Reviewed
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[Journal Article] A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.2012
Author(s)
Egerod KL, Engelstoft MS, ....... Sakata I, Pedersen J, Windelov JA, Fuchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW.
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Journal Title
Endocrinology
Volume: 153
Issue: 12
Pages: 5782-95
DOI
Related Report
Peer Reviewed
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