| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Obesity is a state of chronic, low grade inflammation; it is characterized by increased infiltration of a variety of immune cells into obese adipose tissue. In contrast, nutritional deprivation or malnutrition suppresses immune function, thereby conferring higher susceptibility to infectious diseases. In this study, we focused on leptin, a major adipocyte-derived bioactive substance that is produced in response to the nutritional status, and investigated the role of leptin in the regulation of immune function or inflammation. Leptin deficiency caused impairment of B-cell development in the bone marrow, without affecting monocyte development. On the other hand, CCR2 expression in bone marrow cells was upregulated by obesity, suggesting that leptin induces inflammatory changes of bone marrow cells. These observations suggest that leptin may regulate immune cell functions in response to nutritional status.
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