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Role of leptin signaling in regulation of immune cell functions.

Research Project

Project/Area Number 24790942
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANAKA Miyako  東京医科歯科大学, 医歯(薬)学総合研究科, メディカルフェロー (60622793)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsレプチン / 栄養 / 飢餓 / 免疫 / 炎症
Research Abstract

Obesity is a state of chronic, low grade inflammation; it is characterized by increased infiltration of a variety of immune cells into obese adipose tissue. In contrast, nutritional deprivation or malnutrition suppresses immune function, thereby conferring higher susceptibility to infectious diseases. In this study, we focused on leptin, a major adipocyte-derived bioactive substance that is produced in response to the nutritional status, and investigated the role of leptin in the regulation of immune function or inflammation. Leptin deficiency caused impairment of B-cell development in the bone marrow, without affecting monocyte development. On the other hand, CCR2 expression in bone marrow cells was upregulated by obesity, suggesting that leptin induces inflammatory changes of bone marrow cells. These observations suggest that leptin may regulate immune cell functions in response to nutritional status.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (10 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages.2014

    • Author(s)
      Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y, Ogawa Y.
    • Journal Title

      Diabetes

      Volume: 63 Issue: 1 Pages: 152-61

    • DOI

      10.2337/db13-0757

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肥満症例における脂肪組織の炎症2013

    • Author(s)
      田中 都, 菅波孝祥, 小川佳宏
    • Journal Title

      SURGERY FRONTIER

      Volume: 20 Pages: 31-37

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肥満の病態形成における自然炎症の役割2013

    • Author(s)
      田中 都, 菅波孝祥, 小川佳宏
    • Journal Title

      Annual Review 2013 糖尿病・代謝・内分泌

      Pages: 92-98

    • Related Report
      2013 Final Research Report
  • [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation2012

    • Author(s)
      T. Suganami, M. Tanaka, and Y. Ogawa
    • Journal Title

      Endocr J

      Volume: 59 Pages: 849-857

    • NAID

      10031123130

    • URL

      https://www.jstage.jst.go.jp/article/endocrj/59/10/59_EJ12-0271/_article

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver2012

    • Author(s)
      T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, S. Miura, O. Ezaki, T. Suganami, M. Okano, and Y. Ogawa
    • Journal Title

      Diabetes

      Volume: 61 Pages: 2442-2450

    • URL

      http://diabetes.diabetesjournals.org/content/61/10/2442.long

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脂肪組織炎症とマクロファージ2012

    • Author(s)
      田中 都, 菅波孝祥, 小川佳宏
    • Journal Title

      感染・炎症・免疫

      Volume: 41 Pages: 14-23

    • Related Report
      2013 Final Research Report
  • [Journal Article] ole of DNA methylation in the regulation of lipogenicglycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver2012

    • Author(s)
      Ehara T, Kamei Y, Takahashi M, Yuan X, Kanai S, Tamura E, Tanaka M, Yamazaki T, Miura S, Ezaki O, Suganami T, Okano M, and Ogawa Y
    • Journal Title

      Diabetes

      Volume: 61(10) Issue: 10 Pages: 2442-2450

    • DOI

      10.2337/db11-1834

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation [Review]2012

    • Author(s)
      Suganami T, Tanaka M, Ogawa Y.
    • Journal Title

      Endocrine Journal

      Volume: 59 Issue: 10 Pages: 849-857

    • DOI

      10.1507/endocrj.EJ12-0271

    • NAID

      10031123130

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Mincle, a novel pathogen sensor in macrophages, underlies obesity-induced adipose tissue fibrosis in mice2014

    • Author(s)
      Miyako Tanaka, et al
    • Organizer
      2014 Keystone Symposia for the meeting on Innate Immunity, Metabolism and Vascular Injury
    • Place of Presentation
      Whistler, British Columbia, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Mincle, a novel pathogen sensor in macrophages, underlies obesity-induced adipose tissue fibrosis in mice.2014

    • Author(s)
      Miyako Tanaka, Takayoshi Suganami, Kenji Ikeda, Chikara Komiya, Yoshihiro Ogawa
    • Organizer
      2014 Keystone Symposia for the meeting on Innate Immunity, Metabolism and Vascular Injury
    • Place of Presentation
      Whistler, British Columbia, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪組織炎症における病原体センサー・Mincle の意義2013

    • Author(s)
      田中 都, 他
    • Organizer
      第34回日本肥満学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 肥満の脂肪組織における新規病原体センサーMincle の役割2013

    • Author(s)
      池田賢司, 田中 都, 他
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 肥満に関連する慢性炎症における新規病原体センサーの病態生理的意義2013

    • Author(s)
      田中 都, 他
    • Organizer
      第27回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Role of Macrophage-inducible C-type Lectin in Obesity-induced Adipose Tissue Inflammation2013

    • Author(s)
      Miyako Tanaka, et al
    • Organizer
      2013 Keystone Symposia for the meeting on Adipose tissue inflammation
    • Place of Presentation
      Keystone, Colorado, USA
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 肥満の脂肪組織における新規病原体センサーMincleの役割2013

    • Author(s)
      池田賢司,田中 都,菅波孝祥,小宮力,越智梢,白川伊吹,小川佳宏
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪組織炎症における病原体センサー・Mincleの意義2013

    • Author(s)
      田中 都,菅波孝祥,池田賢司,小宮力,白川伊吹,越智梢,青江誠一郎,亀井康富,小川佳宏
    • Organizer
      第34回日本肥満学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肥満の脂肪組織における新規病原体センサー・Mincle の意義2012

    • Author(s)
      田中 都, 他
    • Organizer
      第33回日本肥満学会学術大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 肥満の脂肪組織における新規病原体センサー・Mincleの意義2012

    • Author(s)
      田中都,菅波孝祥,池田賢司,小宮力,白川伊吹,越智梢,青江誠一郎,亀井康富,小川佳宏
    • Organizer
      第33回日本肥満学会学術大会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Book] 疾患モデルの作製と利用-糖尿病・肥満/感染症2012

    • Author(s)
      田中 都, 他
    • Total Pages
      230
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/cme/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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