Role of leptin signaling in regulation of immune cell functions.
| Project/Area Number |
24790942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Miyako 東京医科歯科大学, 医歯(薬)学総合研究科, メディカルフェロー (60622793)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | レプチン / 栄養 / 飢餓 / 免疫 / 炎症 |
|---|
| Research Abstract |
Obesity is a state of chronic, low grade inflammation; it is characterized by increased infiltration of a variety of immune cells into obese adipose tissue. In contrast, nutritional deprivation or malnutrition suppresses immune function, thereby conferring higher susceptibility to infectious diseases. In this study, we focused on leptin, a major adipocyte-derived bioactive substance that is produced in response to the nutritional status, and investigated the role of leptin in the regulation of immune function or inflammation. Leptin deficiency caused impairment of B-cell development in the bone marrow, without affecting monocyte development. On the other hand, CCR2 expression in bone marrow cells was upregulated by obesity, suggesting that leptin induces inflammatory changes of bone marrow cells. These observations suggest that leptin may regulate immune cell functions in response to nutritional status.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages.2014
Author(s)
Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y, Ogawa Y.
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Journal Title
Diabetes
Volume: 63
Issue: 1
Pages: 152-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver2012
Author(s)
T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, S. Miura, O. Ezaki, T. Suganami, M. Okano, and Y. Ogawa
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Journal Title
Diabetes
Volume: 61
Pages: 2442-2450
URL
Related Report
Peer Reviewed
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[Journal Article] ole of DNA methylation in the regulation of lipogenicglycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver2012
Author(s)
Ehara T, Kamei Y, Takahashi M, Yuan X, Kanai S, Tamura E, Tanaka M, Yamazaki T, Miura S, Ezaki O, Suganami T, Okano M, and Ogawa Y
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Journal Title
Diabetes
Volume: 61(10)
Issue: 10
Pages: 2442-2450
DOI
Related Report
Peer Reviewed
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