| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
There are only to kind of drugs available for pituitary adenomas, including dopamin agonist and somatostatin analog. And surgical treatment is the first choice for the tumors except prolactinomas. We have reported the EGF receptor as a therapeutic target for pituitary adenomas. In this project, we investigated the family of EGF receptor, namely ErbBs in detail. We found ErbB4, especially in Cushing's disease, could be a rarget to suppress the hormone synthesis and secretion from the tumors. This result could be an further development of new drug for these disease.
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