• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of hypothalamo-pituitary damages on female reproductive functions.

Research Project

Project/Area Number 24790946
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionOkayama University

Principal Investigator

NAKAMURA Eri  岡山大学, 大学病院, 医員 (30612634)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生殖内分泌 / 卵巣 / 下垂体 / 生殖内分泌学 / BMP / ステロイド合成
Research Abstract

Ovarian steroidogenesis and folliculogenesis are controlled by pituitary gonadotropins and their receptors expressed in the ovary. In the patients with hypothalamo-pituitary disorders, impairment of reproductive functions often occurs. In that mechanism, not only the reduction of gonadotropins, but also the changes in growth hormone and prolactin, could be involved. In the present study, we investigated the biological impact of pituitary damages on the reproductive functions.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (17 results)

  • [Journal Article] Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells.2013

    • Author(s)
      Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 381 Issue: 1-2 Pages: 8-15

    • DOI

      10.1016/j.mce.2013.07.009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells.2013

    • Author(s)
      Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 375 Issue: 1-2 Pages: 1-9

    • DOI

      10.1016/j.mce.2013.05.010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling2013

    • Author(s)
      Yoshinori Matsumoto,Fumio Otsuka, Mariko Takano-Narazaki, Takayuki Katsuyama, Eri Nakamura, Naoko Tsukamoto, Kenichi Inagaki, Ken-ei Sada, Hirofumi Makino.
    • Journal Title

      Steroids

      Volume: vol.78 Issue: 5 Pages: 513-520

    • DOI

      10.1016/j.steroids.2013.02.011

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells.2013

    • Author(s)
      Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 375 Pages: 1-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis2012

    • Author(s)
      Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Kanako Ogura-Ochi, Tomoko Miyoshi, Kishio Toma, Masaya Takeda, Hirofumi Makino
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: vol.134 Pages: 67-74

    • DOI

      10.1016/j.jsbmb.2012.10.018

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland2012

    • Author(s)
      Yoshinori Matsumoto, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Mariko Takano-Narazaki, Tomoko Miyoshi, Eri Nakamura, Kanako Ogura-Ochi, Masaya Takeda, Hirofumi Makino
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: in press Issue: 1-2 Pages: 8-14

    • DOI

      10.1016/j.jsbmb.2012.04.004

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells.2012

    • Author(s)
      Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Ogura-Ochi K, Tsukamoto N, Takeda M, Makino H.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 358 Issue: 1 Pages: 18-26

    • DOI

      10.1016/j.mce.2012.02.011

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys.2012

    • Author(s)
      Jiro Suzuki, Fumio Otsuka, Yoshinori Matsumoto, Kenichi Inagaki, Tomoko Miyoshi, Masaya Takeda, Naoko Tsukamoto, Eri Nakamura, Kanako Ogura, Hirofumi Makino
    • Journal Title

      Hypertension Research

      Volume: vol.35 Issue: 3 Pages: 312-317

    • DOI

      10.1038/hr.2011.186

    • NAID

      10030644434

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] メラトニンとBMP-6 による卵胞プロゲステロン分泌への影響とその機序2013

    • Author(s)
      中村絵里, 大塚文男, 細谷武史, 寺坂友博, 三好智子, 稲垣兼一, 槇野博史
    • Organizer
      第18回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2013-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Interaction of melatonin and BMP-6 in regulation of steroidogenesis by rat granulosa cells2013

    • Author(s)
      Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Tsukamoto N, Toma K, Terasaka T, Makino H
    • Organizer
      The Endocrine Society's 95th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵胞ステロイド産生における ソマトスタチン反応性の検討2013

    • Author(s)
      中村絵里, 大塚文男, 塚本尚子, 当真貴志雄, 越智可奈子, 三好智子, 稲垣兼一, 武田昌也, 槇野博史
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] Interaction of melatonin and BMP-6 in regulation of steroidogenesis by rat granulosa cells.2013

    • Author(s)
      Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Tsukamoto N, Toma K, Terasaka T, Makino H
    • Organizer
      The Endocrine Society's 95th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel interaction of kisspeptin, estrogen and BMP-4 in GnRH regulation by GT1-7 cells.2013

    • Author(s)
      Terasaka T, Otsuka F, Tsukamoto N, Toma K, Nakamura E, Inagaki K, Ogura-Ochi K, Mark A. Lawson, Makino H
    • Organizer
      The Endocrine Society's 95th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibitory effects of melatonin on adrenocorticotropin production via BMP-4 activation by pituitary corticotrope cells.2013

    • Author(s)
      Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H.
    • Organizer
      The Endocrine Society's 95th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 卵胞ステロイド産生における ソマトスタチン反応性の検討2013

    • Author(s)
      中村絵里、大塚文男、塚本尚子、当真貴志雄、越智可奈子、三好智子、稲垣兼一、武田昌也、槇野博史
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ソマトスタチアンアナログの卵巣ステロイド産生への影響と卵胞BMPシステムの関与2012

    • Author(s)
      中村絵里, 大塚文男, 稲垣兼一, 三好智子, 塚本尚子, 武田昌也, 越智可奈子, 当真貴志雄, 槇野博史
    • Organizer
      第17回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-08
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Effects of BMP-6 on Aldosterone Production by Rat Adrenal Gland In Vivo2012

    • Author(s)
      Miyoshi T, Otsuka F, Matsumoto Y, Inagaki K, Tsukamoto N, Nakamura E, Takano M, Ochi K, Takeda M, Makino H
    • Organizer
      THE ENDOCRINE SOCIETY’S 94th ANNUAL MEETING
    • Place of Presentation
      Houston, TX, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulatory Role of Melatonin and BMP-4 in Prolactin Secretion by Rat Pituitary Lactotrope Cells2012

    • Author(s)
      Ochi K, Otsuka F, Tsukamoto N, Miyoshi T, Nakamura E, Takeda M, Inagaki K, Ogura T, Iwasaki Y, Makino H
    • Organizer
      THE ENDOCRINE SOCIETY’S 94th ANNUAL MEETING
    • Place of Presentation
      Houston, TX, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Kit Iigand-c-kit interaction regulates estradiol production by rat granulose cells via oocyte factors2012

    • Author(s)
      Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Makino H
    • Organizer
      15th INTERNATIONAL AND 14th EUROREAN CONGRESS OF ENDOCRINOLOGY
    • Place of Presentation
      Florence, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] 卵母細胞―顆粒膜細胞間のKL/c-kitおよびGRKによる新たなEstorogen調節系2012

    • Author(s)
      三好智子, 大塚文男, 中村絵里, 稲垣兼一, 槇野博史
    • Organizer
      第17回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] BMPによる骨芽細胞分化に対するエストロゲン作用の検討2012

    • Author(s)
      大塚文男, 楢崎真理子, 松本佳則, 勝山隆行, 中村絵里, 槇野博史
    • Organizer
      第20回日本ステロイドホルモン学会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] 成長ホルモンとソマトスタチン誘導体による卵巣内分泌機能への影響

    • Author(s)
      中村絵里、大塚文男、稲垣兼一、細谷武史、原孝行、当真貴志雄、塚本尚子、槇野博史
    • Organizer
      第9回アクロメガリーフォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成長ホルモンとソマトスタチン作動薬による卵胞ステロイド分泌への影響

    • Author(s)
      中村絵里、大塚文男、稲垣兼一、細谷武史、原孝行、当真貴志雄、塚本尚子、槇野博史
    • Organizer
      第21回日本ステロイドホルモン学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] メラトニンとBMP-6による卵胞プロゲステロン分泌への影響とその機序

    • Author(s)
      中村絵里、大塚文男、細谷武史、寺坂友博、三好智子、稲垣兼一、槇野博史
    • Organizer
      第18回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] GT1-7細胞を用いたKisspeptinによるGnRH分泌調節の検討:BMP-4とEstrogen作用に着目して

    • Author(s)
      寺坂友博、大塚文男、中村絵里、細谷武史、三好智子、稲垣兼一、槇野博史
    • Organizer
      第18回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi