Investigation of Serum Aldosterone Inducing Factors in Patients with Idiopathic Hyperaldosteronism

• Project/Area Number: 24790953
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Keio University
• Principal Investigator: KOBAYASHI Sakiko 慶應義塾大学, 医学部, 共同研究員 (80383727)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 原発性アルドステロン症 / 特発性アルドステロン症 / 高血圧症 / 肥満症 / 内臓脂肪 / 肥満

Research Abstract

Aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA) are the most common subtypes of primary aldosteronism. The etiology of IHA is still unknown and the radical treatment for IHA is not established.In our study, we have shown that 1) urinary aldosterone secretion positively correlated with body mass index, abdominal circumference, fasting blood glucose and HOMA-R only in patients with IHA, not in APA and non-PA patients and 2)the ability to promote aldosterone secretion by serum of IHA patients positively correlated with patients' aldosterone and visceral fat area.These results suggest that there are CYP11B2 activating factors derived from visceral fat in serum of IHA patients and there is a possibility that IHA is improved by amelioration of obesity.

Research Products

• [Presentation] 特発性アルドステロン症の病態における患者血清因子と内臓脂肪の役割 (2013)
  • Author(s): 大山貴子, 栗原 勲, 小林佐紀子, 横田健一, 三石木綿子, 城 理絵, 中村俊文, 宮下和季, 柴田洋孝, 伊藤 裕
  • Organizer: 平成25年度東京高血圧研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-09-28
• [Presentation] 特発性アルドステロン症の病態における患者血清因子の役割 (2013)
  • Author(s): 大山貴子, 柴田洋孝, 栗原 勲, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 林 毅, 城 理絵, 中村俊文, 伊藤 裕
  • Organizer: 第2回臨床高血圧フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2013-05-25
• [Presentation] 肥満を伴う両側性原発性アルドステロン症の病態における患者血清因子の役割 (2013)
  • Author(s): 大山貴子, 柴田洋孝, 栗原 勲, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 林 毅, 城 理絵, 中村俊文, 伊藤 裕
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2013-04-25