| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA) are the most common subtypes of primary aldosteronism. The etiology of IHA is still unknown and the radical treatment for IHA is not established.In our study, we have shown that 1) urinary aldosterone secretion positively correlated with body mass index, abdominal circumference, fasting blood glucose and HOMA-R only in patients with IHA, not in APA and non-PA patients and 2)the ability to promote aldosterone secretion by serum of IHA patients positively correlated with patients' aldosterone and visceral fat area.These results suggest that there are CYP11B2 activating factors derived from visceral fat in serum of IHA patients and there is a possibility that IHA is improved by amelioration of obesity.
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