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Differentiation from mouse ES cells to GH, LH and FSH producing endocrine cells

Research Project

Project/Area Number 24790955
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionNagoya University

Principal Investigator

SUGA Hidetaka  名古屋大学, 医学部附属病院, 病院助教 (20569818)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細胞分化 / 口腔外胚葉 / ラトケ嚢 / GH / LH/FSH
Outline of Final Research Achievements

It has been reported that the oral ectoderm differentiates into anterior pituitary, tooth enamel, nasal epithelium and oral epithelium. In our previous report, we showed the the oral ectoderm differentiation method from mouse ES cells, but the differentiation efficiency was still low. In this study, we succeeded in oral ectoderm induction at high rate by the addition of component X. Moreover, with component Y treatment, mouse ES-derived oral ectoderm differentiates into Rathke's pouch. We established robust differentiation method from mouse ES cells into oral ectoderm, regardless of the lot difference of FBS or KSR.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013

All Journal Article (1 results) Presentation (4 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] 多能性幹細胞から視床下部・下垂体への分化2013

    • Author(s)
      須賀英隆、大磯ユタカ
    • Journal Title

      現代医学

      Volume: 61巻2号 Pages: 191-199

    • Related Report
      2013 Annual Research Report
  • [Presentation] マウスES細胞から視床下部・下垂体への分化とその応用2014

    • Author(s)
      須賀英隆、大磯ユタカ、水野正明
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マウスES細胞から 視床下部-下垂体への分化誘導2013

    • Author(s)
      須賀英隆、大曽根親文、落合啓史、大磯ユタカ
    • Organizer
      第31回内分泌サマーセミナー
    • Place of Presentation
      ゆふいん山水館(大分県由布市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マウスES細胞から視床下部・下垂体への分化と、ヒト細胞への応用2013

    • Author(s)
      須賀英隆
    • Organizer
      日本神経内分泌学会第40回学術集会
    • Place of Presentation
      宮崎市民プラザ(宮崎県宮崎市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マウスES細胞から視床下部・下垂体への分化と、ヒト細胞への応用2013

    • Author(s)
      須賀英隆、大磯ユタカ、水野正明
    • Organizer
      第58回人類遺伝学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 内分泌・糖尿病・代謝内科2013

    • Author(s)
      須賀英隆、大磯ユタカ
    • Total Pages
      166
    • Publisher
      科学評論社
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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