| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Chromosomal translocation and inversion between 3q21 and 3q26 result in misexpression of EVI1 gene on 3q26, which induces leukemogenesis with poor diagnosis. To examine the underlying mechanism of leukemogenesis, we generated a novel mouse model of EVI1-expressing leukemia (3q21q26 mice) harboring a transgene recapitulating the inverted allele by linking two bacterial artificial chromosome (BAC) clones. The 3q21q26 mice suffer from myeloid and lymphoid leukemia after 24 weeks of age. We discovered an abnormal CD34-high cell fraction specifically in the bone marrow of 3q21q26 mice, suggesting that these cells are associated with leukemia.
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