Investigation of biomarkers that enable early diagnosis of graft-versus-host disease

Research Project

Project/Area Number	24790960
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hematology
Research Institution	University of Tsukuba
Principal Investigator	KURITA Naoki 筑波大学, 医学医療系, 講師 (30555561)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	移植片対宿主病 / Notchシグナル / 移植片対腫瘍効果 / 同種造血幹細胞移植 / Notch / NK細胞 / 臍帯血移植 / 再発 / GVHD
Research Abstract	Graft-versus-host disease (GVHD) is a fatal complication of allogeneic stem-cell transplantation (allo-SCT). GVHD-model mice showed that Notch signaling of lymphocytes exacerbates GVHD. Therefore we conducted comprehensive analysis of Notch expression on lymphocytes after allo-SCT by using human samples. As a result, Notch1 was expressed only on NK cells and the expression was significantly higher in recipients of cord-blood transplantation. Not GVHD exacerbation, but reduction of relapse was seen in the recipients whose NK cells expressed Notch1 strongly. This result showed the possibility that enhancing graft-versus-tumor effect without worsening GVHD by manipulating Notch signal.

Report

(3 results)