Research Project
Grant-in-Aid for Young Scientists (B)
Ecotropic viral integration site 1 (Evi1), located on chromosome 3q26, is an independent negative prognostic indicator of survival in acute myeloid leukemia (AML). Thrombocytosis is a characteristic feature in AML patients with 3q26 abnormality, and the platelet function related genes, such as CD41 (integrin aIIb) and cMpl, positively correlates with Evi1 expression in AML patients. Previously, we succeeded in making a mouse model of Evi1-related leukemia. Sub-population of this Evi1 leukemia mice cells expressed both CD41 and cMpl. The CD41+ fraction of Evi1 leukemia mice more efficiently induced secondary leukemia than the CD41- counterpart in a serial BMT assay. The CD41+ cells predominantly expressed cMpl, and shRNA-mediated knockdown of cMpl delayed the progression of Evi1 leukemia in vivo, suggesting that THPO/cMpl signaling is involved in enhancing the growth and survival of Evi1 leukemia cells.
All 2014 2013 2012 Other
All Journal Article (12 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (1 results) Remarks (1 results)
Br J Haematol
Volume: (Epub ahead of print)
Transfusion
Volume: 54(4) Pages: 1093-9
J Obstet Gynaecol Res
Volume: 40 Pages: 1308-16
Blood
Volume: 121(20) Pages: 4142-55
10031196292
Volume: In Press Issue: 3 Pages: 580-91
10.1111/bjh.12726
Int J Hematol
Volume: 98(1) Pages: 56-65
Volume: 97(Review) Pages: 726-34
Transfus Apher Sci
Volume: 49(3) Pages: 673-80
Tissue Antigens
Volume: 81(4) Pages: 227-8
Rinsho Ketsueki
Volume: 54(8) Pages: 749-58
Volume: 121 Issue: 20 Pages: 4142-4155
10.1182/blood-2011-07-368654
臨床検査
Volume: 1 Pages: 34-40
http://www.u-tokyo-hemat.com/research_ronbun.html