Development of leukemia stem cell-specific therapy based on establishment of induced pluripotent stem cells derived from acute myeloid leukemia.

• Project/Area Number: 24790964
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: YOSHIMI Akihide 東京大学, 医学部附属病院, 特任助教 (80609016)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: iPS細胞 / 急性骨髄性白血病 / 慢性骨髄単球性白血病 / 標的遺伝子 / 発現解析 / エピゲノム解析 / 白血病 / エピゲノム / トランスクリプト―ム / 白血病幹細胞

Research Abstract

We tried various strategies using cell sorting , knockdown of p53, administration of some regulators on cell differentiation, and inhibitors of epigenetic regulators to establish acute myeloid leukemia-derived induced plurirpotent stem (iPS) cells. However, these trials resulted in failure. On the other hand, we succeeded in establishing chronic myelomonocytic leukemia (CMMoL)-patients derived iPS (CMMoL-iPS) cells. These CMMoL-iPS cells and hematopoietic cells which were differentiated from CMMoL-iPS cells showed higher proliferation rate compared with normal control cells. In addition, we identified some target genes of CMMoL by analyzing epigenetic and transcriptional profiles of these cells.

Research Products

• [Journal Article] NF-・B/TNF- positive feedback loop with active proteasome machinery supports myeloid leukemia initiating cell capacity (2014)
  • Author(s): Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M
  • Journal Title: Journal of Clinical Investigation Volume: 124 Pages: 528-42
• [Journal Article] ゲノム創薬時代の血液疾患分子標的薬の研究 (2014)
  • Author(s): 吉見昭秀, 黒川峰夫
  • Journal Title: 日本臨牀 Volume: 72 Pages: 1005-1011
• [Journal Article] 白血病幹細胞とclonal evolution (2014)
  • Author(s): 吉見昭秀, 黒川峰夫
  • Journal Title: 日本臨牀 Volume: 72 Pages: 1012-1017
• [Journal Article] AML の予後を規定する遺伝子発現 (2014)
  • Author(s): 吉見昭秀
  • Journal Title: 血液内科 Volume: 68 Pages: 267-272
  • NAID: 40020006999
• [Journal Article] Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity. (2014)
  • Author(s): Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M.
  • Journal Title: J Clin Invest. Volume: 124 Issue: 2 Pages: 528-542
  • DOI: 10.1172/jci68101
  • Peer Reviewed
• [Journal Article] Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16. (2014)
  • Author(s): Ueda K, Yoshimi A, Kagoya Y, Nishikawa S, Marquez VE, Nakagawa M, Kurokawa M.
  • Journal Title: Cancer Science Volume: （in press） Issue: 5 Pages: 0-0
  • DOI: 10.1111/cas.12386
  • Peer Reviewed
• [Journal Article] The shortest isoform of C/EBP・, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model (2013)
  • Author(s): Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M
  • Journal Title: Blood Volume: 121 Pages: 4142-55
• [Journal Article] Successful allogeneic stem cell transplantation for Lennert lymphoma (2013)
  • Author(s): Uni M, Yoshimi A, Nakamura F, Takazawa Y, Fukayama M, Kurokawa M
  • Journal Title: Annals of Hematology Volume: 92 Pages: 859-60
• [Journal Article] A Role for RUNX1 in Hematopoiesis and Myeloid Leukemia (2013)
  • Author(s): Ichikawa M, Yoshimi A, Nakagawa M, Nishimoto N, Watanabe-Okochi N, Kurokawa M
  • Journal Title: International Journal of Hematology Volume: 97 Pages: 726-34
  • NAID: 10031183728
• [Journal Article] Unique association of Waldenström macroglobulinemia with optic neuritis and monoclonal T-cell expansion (2013)
  • Author(s): Morita K, Yoshimi A, Masuda A, Ichikawa M, Yatomi H, Kurokawa M
  • Journal Title: International Journal of Hematology Volume: 98 Pages: 247-9
• [Journal Article] Successful treatment with recombinant thrombomodulin for B-cell lymphomaassociated hemophagocytic syndrome complicated by disseminated intravascular coagulation (2013)
  • Author(s): Uni M, Yoshimi A, Maki H, Maeda D, Nakazaki K, Nakamura F, Fukayama M, Kurokawa M
  • Journal Title: International Journal of Clinical and Experimental Pathology Volume: 6 Pages: 1190-4
  • NAID: 120007089059
• [Journal Article] Treatment with azacitidine for myelodysplastic syndrome transformed from essential thrombocythemia (2013)
  • Author(s): Iizuka H, Yoshimi A, Yamamoto G, Masuda A, Nannya Y, Ichikawa M, Yatomi Y, Kurokawa M
  • Journal Title: Rinsho Ketsueki Volume: 54 Pages: 468-72
• [Journal Article] The shortest isoform of C/EBP・・ Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model (2013)
  • Author(s): Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M
  • Journal Title: Rinsho Ketsueki Volume: 54 Pages: 749-58
• [Journal Article] Transformation of follicular lymphoma in the retroperitoneal muscles demonstrated by CT-guided needle biopsy of FDG-avid lesions; case series (2013)
  • Author(s): Uni M, Nakamura F, Yoshimi A, Shinozaki-Ushiku A, Hosoi A, Nakazaki K, Nannya Y, Fukayama M, Kurokawa M
  • Journal Title: International Journal of Clinical and Experimental Pathology Volume: 7 Pages: 402-6
• [Journal Article] 鉄欠乏性貧血の雑学 (2013)
  • Author(s): 吉見昭秀
  • Journal Title: Medical Practice Volume: 30 Pages: 896-896
• [Journal Article] The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP) , collaborates with Evi1 to induce AML in a mouse BMT model (2013)
  • Author(s): Okochi, N., Yoshimi, A., Sato, T., Ikeda, T., Kumano, K., Taoka, K., Sato, Y., Shinohara, A., Tsuruta, A., Masuda, A., Yokota, H., Yatomi, Y., Takahashi, K., Kitaura, J., Kitamura, T. and Kurokawa, M
  • Journal Title: Blood Volume: 121 Issue: 20 Pages: 4142-4155
  • DOI: 10.1182/blood-2011-07-368654
  • NAID: 10031196292
  • Peer Reviewed
• [Journal Article] Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukaemia. (2013)
  • Author(s): Nukina A, Kagoya Y, Watanabe-Okochi N, Arai S, Ueda K, Yoshimi A, Nannya Y, and Kurokawa M.
  • Journal Title: Br J Haematol Volume: In Press Issue: 3 Pages: 580-91
  • DOI: 10.1111/bjh.12726
  • Peer Reviewed
• [Journal Article] A role for RUNX1 in hematopoiesis and myeloid leukemia. (2013)
  • Author(s): Ichikawa M, Yoshimi A, Nakagawa M, Nishimoto N, Watanabe-Okochi N, and Kurokawa M.
  • Journal Title: Int J Hematol Volume: 97 Issue: 6 Pages: 726-734
  • DOI: 10.1007/s12185-013-1347-3
  • NAID: 10031183728
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma in cirrhotic liver with graft-versus-host disease (2012)
  • Author(s): Yoshimi A, Yamamoto G, Goto T, Fukayama M, Kurokawa M
  • Journal Title: Annals of Hematology Volume: 91 Pages: 1501-2
• [Journal Article] Efficacy of pleural biopsy for diagnosis of pleural effusion due to chronic GVHD after hematopoietic stem cell transplantation (2012)
  • Author(s): Miyauchi M, Yoshimi A, Nannya Y, Takazawa Y, Ichikawa M, Fukayama M, Kurokawa M
  • Journal Title: International Journal of Hematology Volume: 96 Pages: 146-8
  • NAID: 10030954843
• [Journal Article] 難治性AML の遺伝子発現プロファイル (2012)
  • Author(s): 吉見昭秀
  • Journal Title: 血液内科 Volume: 65 Pages: 665-669
• [Journal Article] 難治性AML における遺伝子発現異常 (2012)
  • Author(s): 吉見昭秀, 黒川峰夫
  • Journal Title: 最新医学 Volume: 67 Pages: 2466-2471
• [Journal Article] 正常核型急性骨髄性白血病における遺伝子変異とその意義 (2012)
  • Author(s): 吉見昭秀, 黒川峰夫
  • Journal Title: Medical Practice Volume: 29 Pages: 1295-1298
• [Journal Article] 白血病がん遺伝子Evi1 を介したエピゲノム異常とシグナル異常 (2012)
  • Author(s): 吉見昭秀
  • Journal Title: 血液内科 Volume: 64 Pages: 179-184
• [Journal Article] Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of MLL fusion leukemia through up-regulation of p16
  • Author(s): Ueda K, Yoshimi A, Kagoya Y, Nishikawa S, Marquez V, Nakagawa M, Kurokawa M
  • Journal Title: Cancer Science Volume: (in press)
• [Journal Article] Development of hairy cell leukemia in familial platelet disorder with predisposition to acute myeloid leukemia
  • Author(s): Toya T, Yoshimi A, Morioka T, Arai S, Ichikawa M, Usuki K, Kurokawa M
  • Journal Title: Platelets Volume: (in press)
• [Journal Article] Evi1 Defines Leukemia-initiating Capacity and Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia
  • Author(s): Sato T, Goyama S, Kataoka K, Nasu R, Tsuruta-Kishino T, Kagoya Y, Nukina A, Kumagai K, Kubota N, Nakagawa M, Arai S, Yoshimi A, Honda H, Kadowaki T, Kurokawa M
  • Journal Title: Oncogene Volume: (in press)
• [Journal Article] EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis
  • Author(s): Tanaka M, Suzuki HI, Shibahara J, Kunita A, Isagawa T, Yoshimi A, Kurokawa M, Miyazono K, Aburatani H, Ishikawa S, Fukayama M
  • Journal Title: Oncogene Volume: (in press)
• [Journal Article] Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukaemia
  • Author(s): Nukina A, Kagoya Y, Watanabe-Okochi N, Arai S, Ueda K, Yoshimi A, Nannya Y, Kurokawa M
  • Journal Title: British Journal of Haematology Volume: (in press)
• [Journal Article] Safety of high-dose micafungin for patients with hematological diseases
  • Author(s): Yamazaki S, Nakamura F, Yoshimi A, Ichikawa M, Nannya Y, Kurokawa M
  • Journal Title: Leukemia & Lymphoma Volume: (in press)
• [Presentation] Recurrent CDC25C mutations drive malignant transformation in FPD/AML (2014)
  • Author(s): Akihide Yoshimi, Takashi Toya, Masahito Kawazu, Toshihide Ueno, Ayato Tsukamoto, Hiromitsu Iizuka, Masahiro Nakagawa, Yasuhito Nannya, Shunya Arai, Motoshi Ichikawa, Hironori Harada, Kensuke Usuki, Yasuhide Hayashi, Etsuro Ito, Keita Kirito, Hideaki Nakajima, Hiroyuki Mano, Mineo Kurokawa
  • Organizer: American Association for Cancer Research 2014
  • Place of Presentation: San Diego, USA
• [Presentation] Evi1 Defines Leukemia-initiating Capacity and Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia (2014)
  • Author(s): Tomohiko Sato, Susumu Goyama, Keisuke Kataoka, Ryo Nasu, Takako Tsuruta-Kishino, Yuki Kagoya, Arika Nukina, Katsuyoshi Kumagai, Naoto Kubota, Masahiro Nakagawa, Shunya Arai, Akihide Yoshimi, Hiroaki Honda, Takashi Kadowaki and Mineo Kurokawa
  • Organizer: AACR 2014
  • Place of Presentation: San Diego, USA
• [Presentation] Adiponectin promotes proliferation of hematopoietic cells in vivo (2013)
  • Author(s): Yosuke Masamoto, Shunya Arai, Tomohiko Sato, Akihide Yoshimi, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, Mineo Kurokawa
  • Organizer: The 11th Stem Cell Research Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2013-05-17
• [Presentation] Constitutive NF-kB activation maintained by autocrine TNF-a signaling and active proteasome system supports leukemia stem cell capacity (2013)
  • Author(s): Yuki Kagoya, Akihide Yoshimi, Keisuke Kataoka, Masahiro Nakagawa, Kumano Keiki, Shunya Arai, Mineo Kurokawa
  • Organizer: The 11th Stem Cell Research Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2013-05-17
• [Presentation] 家族性血小板異常症の病態解析 (2013)
  • Author(s): 飯塚浩光, 吉見昭秀, 間野博行, 荒井俊也, 黒川峰夫
  • Organizer: 第17回造血器腫瘍研究会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-02-02
• [Presentation] NF-kB/TNF-a positive feedback loop with active proteasome system controls leukemia stem cell capacity (2013)
  • Author(s): Yuki Kagoya, Akihide Yoshimi, Keisuke Kataoka, Masahiro Nakagawa, Keiki Kumano, Shunya Arai, Mineo Kurokawa
  • Organizer: Keystone Symposia Stem Cell Regulation in Homeostasis and Disease
  • Place of Presentation: Banff, Alberta, Canada
• [Presentation] EZH2 targeting as a therapeutic strategy against MLL fusion leukemia stem cell (2013)
  • Author(s): Koki Ueda, Akihide Yoshimi, Masahiro Nakagawa, Satoshi Nishikawa, Keiki Kumano, and Mineo Kurokawa
  • Organizer: Keystone Symposia Stem Cell Regulation in Homeostasis and Disease
  • Place of Presentation: Banff, Alberta, Canada
• [Presentation] 発難治性T細胞リンパ腫にに対するmodified ESHAP療法の後方視的検討 (2013)
  • Author(s): 木暮泰寛, 吉見昭秀, 植田航希, 南谷泰仁, 市川幹, 中村文彦, 黒川峰夫
  • Organizer: 第53回リンパ網内系学会総会
  • Place of Presentation: 京都
• [Presentation] TNFa の自己分泌能と高いプロテアソーム活性によるNF-kB の恒常的活性化が骨髄性白血病幹細胞の増殖に重要な役割を担う (2013)
  • Author(s): 籠谷勇紀, 吉見 昭秀, 黒川 峰夫
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] Pathological analysis of familial platelet disorder with propensity to myeloid malignancy (2013)
  • Author(s): Akihide Yoshimi, Hiromitsu Iizuka, Takashi Toya, Tomohiko Sato, Masahito Kawazu, Keiki Kumano, Motoshi Ichikawa, Keita Kirito, Hiroyuki Mano, Shunya Arai, Mineo Kurokawa
  • Organizer: Runx Workshop 2013
  • Place of Presentation: Wilsede, Germany
• [Presentation] Exome sequencing combined with single cell sequencing reveals genetic mechanisms of malignant transformation in FPD/AML (2013)
  • Author(s): Akihide Yoshimi, Takashi Toya, Hiromitsu Iizuka, Shunya Arai, Masahiro Nakagawa, Masahito Kawazu, Motoshi Ichikawa, KeitaKirito, Hiroyuki Mano, Mineo Kurokawa
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: Yokohama, Japan
• [Presentation] JAK2V617F mutation evokes paracrine DNA damage to adjacent cells and drives leukemic transformation (2013)
  • Author(s): Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Keisuke Kataoka, Shunya Arai, Mineo Kurokawa
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Clonal and mutational evolution reveals genetic mechanisms of leukemia transformation of FPD/AML (2013)
  • Author(s): 吉見 昭秀, 遠矢 嵩, 飯塚 浩光, 荒井 俊也, 中川 正宏, 河津 正人, 市川 幹, 桐戸 敬太, 間野 博行, 黒川 峰夫
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: Sapporo, Japan
• [Presentation] JAK2V617F mutation evokes paracrine DNA damage to adjacent cells and drives leukemic transformation (2013)
  • Author(s): 籠谷 勇紀, 吉見 昭秀, 鶴田貴子, 片岡 圭亮, 荒井 俊也, 黒川 峰夫
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: Sapporo, Japan
• [Presentation] Modified ESHAP regimen for relapsed/refractory T-cell lymphoma : A retrospective analysis (2013)
  • Author(s): 木暮 泰寛, 吉見 昭秀, 植田 航希, 南谷 泰仁, 市川 幹, 中村 文彦, 黒川 峰夫
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: Sapporo, Japan
• [Presentation] Adiponectin promotes proliferation of hematopoietic cells in vivo (2013)
  • Author(s): 正本 庸介, 荒井 俊也, 佐藤 智彦, 吉見 昭秀, 高本 偉碩, 窪田 直人, 門脇 孝, 黒川 峰夫
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: Sapporo, Japan
• [Presentation] Identification of miRNA targeting Evi1 (2013)
  • Author(s): 山本 春菜, 横山 和明, 呂 軍, 大庭 成喜, 川俣 豊隆, 吉見 昭秀, 森下 和広, 黒川 峰夫, 幸谷 愛
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: Sapporo, Japan
• [Presentation] The Genetic Landscape Of FPD/AML Revealed CDC25C Mutation As a Driver That Promotes Malignant Transformation (2013)
  • Author(s): Akihide Yoshimi, Takashi Toya, Masahiro Nakagawa, Masahito Kawazu, Yasuhito Nannya, Motoshi Ichikawa, Shunya Arai, Hironori Harada, Kensuke Usuki, Yasuhide Hayashi, Etsuro Ito, Keita Kirito, Hideaki Nakajima, Hiroyuki Mano and Mineo Kurokawa
  • Organizer: 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
• [Presentation] JAK2V617F Mutation Evokes Paracrine DNA Damage To Adjacent Normal Cells Via Secretion Of Lipocalin-2 (2013)
  • Author(s): Yuki Kagoya, Shunya Arai, Akihide Yoshimi, Takako Tsuruta-Kishino1, Keisuke Kataoka and Mineo Kurokawa
  • Organizer: 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
• [Presentation] Anti-Obese Hormone Adiponectin Regulates Emergency Hematopoiesis and Antibacterial Response Through Downregulation Of Socs3 In Hematopoietic Progenitor Cells (2013)
  • Author(s): Yosuke Masamoto, Shunya Arai, Tomohiko Sato, Akihide Yoshimi, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki and Mineo Kurokawa
  • Organizer: 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
• [Presentation] A Randomized Controlled Study Evaluating The Efficacy Of Aprepitant For Highly Emetogenic Chemotherapies In Hematological Malignancies (2013)
  • Author(s): Ryo Nasu, Yasuhito Nannya, Akihide Yoshimi, Masataka Hosoi, Kouki Ueda, Yumiko Yoshiki, Shunya Arai, Akihito Shinohara, Fumihiko Nakamura and Mineo Kurokawa
  • Organizer: 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
• [Presentation] Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukemia (2013)
  • Author(s): 貫名有香, 籠谷勇紀, 大河内直子, 植田航希, 吉見昭秀, 南谷泰仁, 荒井俊也, 黒川峰夫
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] The Genetic Landscape Of FPD/AML Revealed CDC25C Mutation As a Driver That Promotes Malignant Transformation (2013)
  • Author(s): Akihide Yoshimi, Takashi Toya, Masahiro Nakagawa, Masahito Kawazu, Yasuhito Nannya, Motoshi Ichikawa, Shunya Arai, Hironori Harada, Kensuke Usuki, Yasuhide Hayashi, Etsuro Ito, Keita Kirito, Hideaki Nakajima, Hiroyuki Mano, Mineo Kurokawa
  • Organizer: 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New orleans, USA
• [Presentation] Clonal and mutational evolution reveals genetic mechanisms of leukemia transformation of FPD/AML (2013)
  • Author(s): 吉見昭秀、遠矢嵩、飯塚浩光、荒井俊也、中川正宏、河津正人、市川幹、桐戸敬太、間野博行、黒川峰夫
  • Organizer: 日本血液学会
  • Place of Presentation: 札幌
• [Presentation] Exome sequencing combined with single cell sequencing reveals genetic mechanisms of malignant transformation in FPD/AML (2013)
  • Author(s): 吉見昭秀、遠矢嵩、飯塚浩光、荒井俊也、中川正宏、河津正人、市川幹、桐戸敬太、間野博行、黒川峰夫
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
• [Presentation] Pathological analysis of familial platelet disorder with propensity to myeloid malignancy (2013)
  • Author(s): Akihide Yoshimi, Hiromitsu Iizuka, Takashi Toya, Tomohiko Sato, Masahito Kawazu, Keiki Kumano, Motoshi Ichikawa, Keita Kirito, Hiroyuki Mano, Shunya Arai, Mineo Kurokawa
  • Organizer: RUNX Workshop
  • Place of Presentation: Wilsede, Germany
• [Presentation] 家族性血小板異常症の病態解析 (2013)
  • Author(s): 吉見昭秀、飯塚浩光、間野博行、荒井俊也 、黒川峰夫
  • Organizer: 造血器腫瘍研究会
  • Place of Presentation: 宮崎
• [Presentation] Evi1はポリコーム複合体との相互作用を介してエピジェネティックにPTEN の発現を抑制し, AKT/mTOR シグナルを活性化する (2012)
  • Author(s): 吉見昭秀, 合山進, 渡辺-大河内直子, 吉識由美子, 南谷泰仁, 仁田英里子, 荒井俊也, 佐藤智彦, 島辺宗健, 中川正宏, 今井陽一, 北村俊雄, 黒川峰夫
  • Organizer: 第8回血液学若手研究者勉強会(麒麟塾)
  • Place of Presentation: 品川
  • Year and Date: 2012-07-07
• [Presentation] NF-kB-TNF-a positive feedback loop is universally essential for maintenance of myeloid leukemia stem cells (2012)
  • Author(s): Yuki Kagoya, Akihide Yoshimi, Shunya Arai, Masahiro Nakagawa, Keiki Kumano, Mineo Kurokawa
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: Sapporo, Japan
• [Presentation] The histone methyltransferase EZH2 plays a crucial role in MLL-related leukemia (2012)
  • Author(s): Koki Ueda, Akihide Yoshimi, Masahiro Nakagawa, Satoshi Nishikawa, Keiki Kumano, Mineo Kurokawa
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: Sapporo, Japan
• [Presentation] NF-kB-TNF-a positive feedback loop is essential for maintenance of myeloid leukemia stem cells (2012)
  • Author(s): Yuki Kagoya, Akihide Yoshimi, Shunya Arai, Masahiro Nakagawa, Keiki Kumano, Mineo Kurokawa
  • Organizer: 第74回日本血液学会総会
  • Place of Presentation: Kyoto, Japan
• [Presentation] The histone methyltransferase EZH2 plays a crucial role in MLL-related leukemia (2012)
  • Author(s): Koki Ueda, Akihide Yoshimi, Masahiro Nakagawa, Satoshi Nishikawa, Keiki Kumano, Mineo Kurokawa
  • Organizer: 第74回日本血液学会総会
  • Place of Presentation: Kyoto, Japan
• [Presentation] Identification of microRNAs targeting Evi-1 (2012)
  • Author(s): Jun Lu1 Shigeyoshi Oba, Akihide Yoshimi, Kiyoshi Ando, Kazuhiro Morishita, Mineo Kurokawa, Ai Kotani
  • Organizer: 第74回日本血液学会総会
  • Place of Presentation: Kyoto, Japan
• [Presentation] NF-κB/TNF-α Positive Feedback Loop with Active Proteasome Machinery Supports Myeloid Leukemia Initiating Cell Capacity (2012)
  • Author(s): Yuki Kagoya, Akihide Yoshimi, Shunya Arai, Keisuke Kataoka, Masahiro Nakagawa, Keiki Kumano and Mineo Kurokawa
  • Organizer: 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] Inhibition of EZH2 Depletes MLL Fusion Leukemia Stem Cells Through Restoration of p16 Expression (2012)
  • Author(s): Koki Ueda, Akihide Yoshimi, Masahiro Nakagawa, Satoshi Nishikawa, Victor E Marquez, Keiki Kumano and Mineo Kurokawa
  • Organizer: 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA, USA
• [Book] 『カラーテキスト血液病学第2 版』(in Japanese)第2 章D.骨髄系腫瘍の発症機構 (2013)
  • Author(s): 吉見昭秀, 黒川峰夫
• [Book] 『カラーテキスト血液病学第2版』 (2013)
  • Author(s): 吉見昭秀、黒川峰夫（木崎昌弘編著）
  • Total Pages: 688
  • Publisher: 中外医学社
• [Remarks]
  • URL: https://sites.google.com/site/akihideyoshimi/website_akihideyoshimi
• [Remarks] Website_AkihideYoshimi
  • URL: https://sites.google.com/site/akihideyoshimi/website_akihideyoshimi
• [Remarks] 血液・腫瘍内科|東京大学医学部附属病院
  • URL: http://www.u-tokyo-hemat.com/
• [Remarks] Website_AkihideYoshimi
  • URL: https://sites.google.com/site/akihideyoshimi/website_akihideyoshimi