Restoration of Treg homeostasis with Low-dose IL-2 administiration for patients with refractory chronic GVHD
Project/Area Number |
24790975
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Okayama University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | GVHD / 制御性T細胞 / 免疫寛容 / インターロイキン2 / 移植片対宿主病 / 移植免疫 / 橋渡し研究 / 細胞療法 / 造血幹細胞移植 |
Research Abstract |
CD4+CD25+Foxp3+ regulatory T cell (Treg) has a central role in maintaining immune tolerance and interleukin-2 (IL-2) is critical for Treg growth, survival and activity. We reported that administration of low-dose IL-2 could preferentially enhance Treg in vivo and suppress clinical manifestations of chronic GVHD after allogeneic hematopoietic stem cell transplantation, suggesting the therapeutic potential of low-dose IL-2 to reconstruct immune tolerance in vivo. Our murine experiments of low-dose IL-2 therapy demonstrated that in vivo effect of exogenous IL-2 is susceptible to several external factors, including the host immune status and the dose or timing of IL-2 administration. These findings will be important information to explore the individualized IL-2 therapy that enables to standardize and optimize this cytokine therapy.
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Mammalian target of rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease.2014
Author(s)
Sugiyama H, Maeda Y, Nishimori H, Yamasuji Y, Matsuoka K, Fjii N, Kondo E, Shinagawa K, Takeuchi K, Teshima T, and Tanimoto M
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Journal Title
Biol Blood Marrow Transplant.
Volume: 20
Issue: 2
Pages: 183-91
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bronchiolitis obliterans with allogeneic hematopoietic cell transplantation: a 10-year experience of the Okayama BMT Group.2014
Author(s)
Fujii N, Nakase K, Asakura S, Matsuo K, Nawa Y, Sunami K, Nishimori H, Matsuoka KI, Kondo E, Maeda Y, Shinagawa K, Hara M, Tanimoto M.
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Journal Title
Int J Hematol.
Volume: 99
Issue: 5
Pages: 1556-1556
DOI
Related Report
Peer Reviewed
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[Journal Article] Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease2013
Author(s)
Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, Murase K, Cutler C, Ho VT, Alyea EP, Armand P, Blazar BR, Antin JH, Soiffer RJ, Ritz J.
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Journal Title
Science Translational Medicine
Volume: 5
Issue: 179
Pages: 179-190
DOI
Related Report
Peer Reviewed
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[Journal Article] CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells.2013
Author(s)
Naito M, Hainz U, Burkhardt UE, Fu B, Ahove D, Stevenson KE, Rajasagi M, Zhu B, Alonso A, Witten E, Matsuoka K, Neuberg D, Wu CJ, Freeman GJ
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Journal Title
Cancer Immunol Immunother.
Volume: 62
Issue: 2
Pages: 347-57
DOI
Related Report
Peer Reviewed
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[Journal Article] Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC)2012
Author(s)
Vasir B, Zarwan C, Ahmad R, Crawford K, Rajabi H, Matsuoka K, Rosenblatt J, Wu Z, Mills H, Kufe D, Avigan D
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Journal Title
J Immunotherapy
Volume: 35(7)
Issue: 7
Pages: 555-69
DOI
Related Report
Peer Reviewed
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[Presentation] Chronic inflammatory demyelinating polyradiculoneuropathy following low-dose donor lymphocyte infusion after haplo-identical hematopoietic stem cell transplantation2013
Author(s)
Taiga Kuroi, Ken-ichi Matsuoka, Takanori Yoshioka, Yusuke Meguri, Kyosuke Saeki, Eiko Hasegawa, Takeru Asano, Nobuharu Fujii, Eisei Kondo, Yoshinobu Maeda, Katsuji Shinagawa, Shoko Deguchi, Kentaro Deguchi, Makoto Takeuchi and Mitsune Tanimoto
Organizer
日本血液学会国際シンポジウム
Place of Presentation
愛媛県松山市
Related Report
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[Presentation] Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells2013
Author(s)
Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Robert W Smith, Kristen Cowens, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony Letai, Jerome Ritz
Organizer
Annual meeting of American Society of Hematology
Place of Presentation
米国ニューオーリンズ
Related Report
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