| Project/Area Number |
24790977
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 組織幹細胞 / 腸幹細胞 / 移植片対宿主病 / パネート細胞 / 脂肪前駆細胞 / 脱毛 / GVHD / 造血幹細胞移植 / REGIIIα / 皮膚幹細胞 |
|---|
| Research Abstract |
The efficacy of allogeneic stem cell transplantation (allo-SCT) is limited by the devastating complication, graft-versus-host disease (GVHD). We evaluated a link between GVHD induced tissue damage and tissue stem cells.
We discovered that Paneth cells, which are identified as niche for intestinal stem cells, are targeted by GVHD, resulting in marked reduction in the expression of alfa-defensins. GVHD associated changes in production of antimicrobial peptides including alfa-defensins delivered loss of physiological diversity among the intestinal microflora. We also found the possibilities that pretransplant conditioning regimen damaged adipose precursor cells, which function as skin stem cell niche to drive hair cycling, and the process of adipose precursor cell recovery was inhibited by chronic GVHD development, resulting in alopecia.
Therefore, protection of tissue stem cells as well as their niche from GVHD may ameliorate tissue damage and promote tissue regeneration after allo-SCT.
|
