Identification of gene sets for prognostic prediction of acute myelogenous leukemia

• Project/Area Number: 24790980
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Fukushima Medical University
• Principal Investigator: MATSUMOTO Hayato 福島県立医科大学, 医学部, 研究員 (70528083)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: マイクロアレイ / 予後予測 / DNAマイクロアレイ / 急性骨髄性白血病 / 腫瘍マーカー

Outline of Final Research Achievements

To develop a method for predicting outcomes in acute myelogenous leukemia (AML) , we analyzed a number of leukemia bone marrow samples by DNA microarray and identified 68 genes that may be related to patient outcomes. Cluster analysis by comparison with a previously reported scoring system to predict outcomes showed that outcomes in AML　could be classified as good or poor on the basis of 20 genes. To examine the usefulness of this 20-gene set, the expression of the genes was examined in bone marrow samples from patients for whom outcomes were already known as a validation cohort. We also used DNA microarray to identify genes involved in the transformation from myelodysplastic syndrome to AML and examined them further in detail.

Research Products

• [Journal Article] Somatic 15q break after long-term stable disease in acute myeloid leukemia (2014)
  • Author(s): Harada-Shirado K, Ikeda K, Matsumoto H, Shiga Y, Furukawa M, Takahashi H, Ohkawara H, Noji H, Hashimoto Y, Waguri S, Watanabe S, Ogawa K, Takeishi Y
  • Journal Title: Clinical Lymphoma, Myeloma & Leukemia Volume: 14 Issue: 2 Pages: e69-e72
  • DOI: 10.1016/j.clml.2013.10.009
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of 1.0% chlorhexidine-gluconate ethanol compared with 10% povidone-iodine for long-term central venous catheter care in hematology departments: A prospective study (2014)
  • Author(s): Yamamoto N, Kimura H, Misao H, Matsumoto H, Imafuku Y, Watanabe A, Mori H, Yoshida A, Miura S, Abe Y, Toba M, Suzuki H, Ogawa K, Kanemitsu K
  • Journal Title: American Journal of Infection Control Volume: 42 Issue: 5 Pages: 574-576
  • DOI: 10.1016/j.ajic.2013.12.023
  • Peer Reviewed / Open Access
• [Presentation] Double Ph染色体にmicro BCR-ABLを伴ったCMLの一例
  • Author(s): 原田佳代, 池田和彦, 古川未希, 高橋裕志, 松本勇人, 大河原浩, 野地秀義, 田崎和洋, 小川一英, 竹石恭知
  • Organizer: 第19回 造血器腫瘍研究会
  • Place of Presentation: 福島市
• [Presentation] Breast tumor as a presentation of extranodal T-cell lymphoblastic lymphoma-clinical and pathological analysis
  • Author(s): Harada-Shirado K, Ikeda K, Hashimoto Y, Kawana S, Matsumoto H, Ohkawara H, Noji H, Abe M, Ogawa K, Takeishi Y
  • Organizer: The 4th JSH International Symposium 2013 in Ehime
  • Place of Presentation: Matsuyama, Japan
• [Presentation] ラスブリカーゼにより透析離脱後、寛解に導入し得たバーキットリンパ腫/白血病の一例
  • Author(s): 阿部 理, 池田和彦, 原田佳代, 古川未希, 松本勇人, 助川真純, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 小川一英, 竹石恭知
  • Organizer: 第60回 福島血液研究会
  • Place of Presentation: 福島市
• [Presentation] Expression of NECDIN in acute myeloid leukemia (AML)
  • Author(s): Ikeda K, Ogawa K, Harada-Shirado K, Shiga Y, Furukawa M, Takahashi H, Matsumoto H, Ohkawara H, Noji H, Takeishi Y
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] POEMS症候群に対してauto PBSCTを施行した一例
  • Author(s): 助川真純, 高橋裕志, 大河原浩, 七島晶子, 横川哲朗, 古川未希, 原田佳代, 松本勇人, 池田和彦, 野地秀義, 小川一英, 大戸 斉, 竹石恭知
  • Organizer: 第36回 日本造血細胞移植学会総会
  • Place of Presentation: 宜野湾市