The role of Aiolos in allergic airway inflammation
Project/Area Number |
24790989
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | アレルギー性気道炎症 / ヘルパーT細胞分化 / アレルギー疾患 / 免疫学 / CD4T細胞 / Aiolos |
Research Abstract |
It has been shown that Aiolos is a transcription factor whose expression is restricted to hemopoietic cells. However, the regulatory mechanisms of Aiolos expression in CD4+ T cells and its roles in allergic inflammation remain largely unknown. In this study, we found that IL-4 induced Aiolos expression in murine CD4+ T cells through a Stat6-dependent manner, whereas Aiolos expression did not affect Th2 cytokine production in CD4+ T cells. We also found that the expression of Aiolos in the lung was up-regulated in OVA-induced allergic airway inflammation but not in papain-induced airway inflammation in mice. In addition, we found that gene expression of Aiolos strongly correlated with those of TNFRSF4 (OX40) and TNFRSF18 (GITR) in human CD4+ T cells. These results suggest that Aiolos may control the function of CD4+ T cells by regulating the expression of OX40 or GITR in CD4+ T cells.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment2013
Author(s)
Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori H, Suzuki K, Takabayashi K, Nakajima H
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Journal Title
Arthritis Rheum
Volume: 65(4)
Pages: 890-8
Related Report
Peer Reviewed
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[Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity2013
Author(s)
Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H
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Journal Title
J Invest Dermatol
Volume: 133(3)
Pages: 702-11
Related Report
Peer Reviewed
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[Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity.2013
Author(s)
Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H.
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Journal Title
J Invest Dermatol.
Volume: 133
Issue: 3
Pages: 702-702
DOI
Related Report
Peer Reviewed
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[Journal Article] Annexin A10 in human oral cancer : biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways2012
Author(s)
Shimizu T, Kasamatsu A, Yamamoto A, Koike K, Ishige S, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Annexin A10 in human oral cancer: biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways.2012
Author(s)
Shimizu T, Kasamatsu A, Yamamoto A, Koike K, Ishige S, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K
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Journal Title
PLoS One
Volume: 7
Issue: 9
Pages: e45510-e45510
DOI
Related Report
Peer Reviewed
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[Presentation] Ultrasonographic assessment of synovitis improves the accuracy of 2010 American College of Rheumatology/ European League Against Rheumatism classification criteria for rheumatoid arthritis to predict development of a methotrexate-requiring disease
Author(s)
Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori H, Suzuki K, Takabayashi K, and Nakajima H
Organizer
EULAR congress
Place of Presentation
Berlin/Germany
Related Report
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