Identification of the origin of pathogenic synovial fibroblasts in rheumatoid arthritis

Research Project

Project/Area Number	24790994
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	膠原病・アレルギー・感染症内科学
Research Institution	Tokyo Medical and Dental University
Principal Investigator	MIZOGUCHI Fumitaka 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60510360)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	関節リウマチ / 線維芽細胞 / 間葉系幹細胞 / 血球系幹細胞 / 滑膜線維芽細胞 / 幹細胞
Research Abstract	Synovial fibroblasts play crucial role in the pathogenesis of rheumatoid arthritis. They produce inflammatory cytokines and proteinases to cause the joint destruction. However, it has not yet been clarified how such pathogenic synovial fibroblasts are formed in rheumatoid arthritis. Identifying the progenitor cells of the pathogenic synovial fibroblasts and the regulatory mechanisms could lead to the development of the new strategies to treat rheumatoid arthritis. In this study, we examined the origin of the pathogenic synovial fibroblasts by using murine model of arthritis. We identified the cell type and the localization of the progenitor cells.