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Multilateral research to build a new standard management of RA using non-invasive and high-sensitive imaging

Research Project

Project/Area Number 24791000
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNagasaki University

Principal Investigator

KAWASHIRI Shin-ya  長崎大学, 医歯(薬)学総合研究科, 助教 (20457576)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords関節リウマチ / 超音波 / MRI / 骨膜炎 / 骨炎(骨髄浮腫) / 早期分類基準 / 治療反応性予測 / バイオマーカー / MRI / 滑膜炎 / 関節超音波 / PDUS滑膜炎 / MRI骨炎 / 早期診断基準 / 関節破壊進行予測
Research Abstract

1. The important findings of image in the early classification of RA were ultrasound-proven synovitis (power Doppler grade 2 or 3) and MRI-proven osteitis. The frequency and severity of both findings were significantly correlated. 2. The improvement of ultrasound synovitis scores during 3 months reflected the clinical therapeutic response at 6 months in RA patients treated with biologic disease-modifying anti-rheumatic drugs (DMARDs). Angiogenic factors such as VEGF and angiopoitin-2 were suggested to correlate with therapeutic response. 3.The ABVS system performed in mammary glands was able to apply to ultrasound of wrist and finger joints and the automatic scanning system has been established toward patients with RA.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (21 results) (of which Invited: 1 results)

  • [Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis2014

    • Author(s)
      Shin-ya Kawashiri, Takahisa Suzuki, Yoshikazu Nakashima, 他13名
    • Journal Title

      Rheumatology (Oxford)

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.2014

    • Author(s)
      Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 53 Issue: 3 Pages: 562-569

    • DOI

      10.1093/rheumatology/ket405

    • NAID

      120006986675

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.2014

    • Author(s)
      Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
    • Journal Title

      Rheumatology (Oxford).

      Volume: -

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of ultrasound subclinical synovitis and increment of serum vascular endothelial growth factor in a patient with rheumatoid arthritis achieved in sustained clinical remission by treatment with adalimumab and methotrexate.2014

    • Author(s)
      Kawashiri SY, Arima K, Suzuki T, Nakashima Y, Horai Y, Okada A, Tamai M, Nakamura H, Kawakami A.
    • Journal Title

      Mod Rheumatol.

      Volume: -

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confirmation of effectiveness of tocilizumab by ultrasonography and magnetic resonance imaging in biologic agent-naïve early-stage rheumatoid arthritis patients.2014

    • Author(s)
      Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Kawakami A.
    • Journal Title

      Mod Rheumatol.

      Volume: -

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of ultrasonography-proven tenosynovitis to monitor disease activity of a patient with very early rheumatoid arthritis treated by abatacept.2013

    • Author(s)
      Kawashiri SY, Fujikawa K, Nishino A, Suzuki T, Okada A, Nakamura H, Kawakami A.
    • Journal Title

      Mod Rheumatol.

      Volume: 23 Issue: 3 Pages: 582-586

    • DOI

      10.1007/s10165-012-0680-3

    • NAID

      10031175921

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 関節リウマチ患者における抗リウマチ薬治療による関節超音波パワードプラスコアと血管新生因子血清濃度の改善2013

    • Author(s)
      川尻 真也, 鈴木 貴久, 中島 好一, 寶來 吉朗, 岩本 直樹, 一瀬 邦弘, 中村 英樹, 川上 純, 玉井 慎美, 折口 智樹, 有馬 和彦, 青柳 潔
    • Journal Title

      九州リウマチ

      Volume: 33 Pages: 74-80

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of ultrasound subclinical synovitis and increment of serum vascular endothelial growth factor in a patient with rheumatoid arthritis achieved in sustained clinical remission by treatment with adalimumab and methotrexate.2013

    • Author(s)
      Kawashiri SY, Arima K, Suzuki T, Nakashima Y, Horai Y, Okada A, Tamai M, Nakamura H, Kawakami A.
    • Journal Title

      Modern Rheumatology

      Volume: -

    • DOI

      10.1007/s10165-012-0821-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis.2012

    • Author(s)
      Kawashiri SY, Suzuki T, Okada A, Yamasaki S, Tamai M, Nakamura H, Origuchi T, Mizokami A, Uetani M, Aoyagi K, Eguchi K, Kawakami A
    • Journal Title

      Mod Rheumatol

      Volume: 23 Issue: 1 Pages: 36-43

    • DOI

      10.1007/s10165-012-0628-7

    • NAID

      10031167664

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 関節超音波所見が鑑別診断に重要であった慢性痛風性関節炎の一例.2012

    • Author(s)
      川尻 真也, 鈴木 貴久, 中島 好一, 寶來 吉朗, 一瀬 邦弘, 中村 英樹, 川上 純, 折口 智樹, 青柳 潔
    • Journal Title

      九州リウマチ

      Volume: 32 Pages: 123-127

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Ultrasound disease activity at 3 months predicts the clinical response at 6 months of patients with rheumatoid arthritis treated by biologic disease modifying anti-rheumatic drugs2014

    • Author(s)
      川尻 真也
    • Organizer
      EULAR2014
    • Place of Presentation
      フランスパリ
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 超音波を用いた関節リウマチの診断と治療の評価:MRIとの比較を含めて2014

    • Author(s)
      川尻真也,玉井慎美,上谷雅孝,青柳潔,川上純
    • Organizer
      第58回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京都港区グランドプリンスホテル新高輪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 早期関節リウマチ患者において手指の機能障害に関連するのは関節滑膜炎か腱鞘滑膜炎か?2014

    • Author(s)
      川尻真也、西野文子、高谷亜由子、鈴木貴久、寶來吉朗、中島好一、岩本直樹、一瀬邦弘、玉井慎美、有馬和彦、中村英樹、折口智樹、青柳潔、川上純
    • Organizer
      第47回九州リウマチ学会
    • Place of Presentation
      長崎県長崎市ブリックホール
    • Related Report
      2013 Annual Research Report
  • [Presentation] The severity of synovial inflammation assessed by musculoskeletal ultrasonography correlates with that of osteitis assessed by magnetic resonance imaging in patients with rheumatoid arthritis2013

    • Author(s)
      川尻 真也
    • Organizer
      EULAR2013
    • Place of Presentation
      スペインマドリッド
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Automated Breast Volume Scanner (ABVS), a new automated ultrasonic device, is useful to examine joint injury in patients with rheumatoid arthritis2013

    • Author(s)
      川尻 真也
    • Organizer
      EULAR2013
    • Place of Presentation
      スペインマドリッド
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ACUSON S2000 ABVS (Automated Breast Volume Scanner)を用いた関節リウマチ患者における手指関節自動スキャンの検討2013

    • Author(s)
      川尻真也、鈴木貴久、中島好一、寶來吉朗、岡田覚丈、岩本直樹、一瀬邦弘、玉井慎美、有馬和彦、中村英樹、折口智樹、上谷雅孝、青柳潔、川上純
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      京都府京都市国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] Automated Breast Volume Scanner (ABVS), a new automated ultrasonic device, is useful to examine joint injury in patients with rheumatoid arthritis2013

    • Author(s)
      Shin-ya Kawashiri, Takahisa Suzuki, Yoshikazu Nakashima, Yoshiro Horai, Akitomo Okada, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Kazuhiko Arima, Hideki Nakamura, Tomoki Origuchi, Masataka Uetani, Kiyoshi Aoyagi, Atsushi Kawakami
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      京都府京都市国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] ACUSON S2000 ABVS (Automated Breast Volume Scanner)を用いた関節リウマチ患者における手指関節自動スキャンの検討2013

    • Author(s)
      川尻真也、鈴木貴久、中島好一、寶來吉朗、玉井慎美、中村英樹、折口智樹、上谷雅孝、青柳潔、川上純
    • Organizer
      第110回日本内科学会総会
    • Place of Presentation
      東京都港区グランドプリンスホテル新高輪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者において関節超音波滑膜炎の重症度はMRI骨炎の重症度と関連する2013

    • Author(s)
      川尻真也、西野文子、鈴木貴久、中島好一、寶來吉朗、岩本直樹、一瀬邦弘、玉井慎美、有馬和彦、中村英樹、折口智樹、上谷雅孝、青柳潔、川上純
    • Organizer
      第28回日本臨床リウマチ学会
    • Place of Presentation
      千葉県千葉市幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Power Doppler assessment of synovial vascularity predicts the presence of magnetic resonance imaging-proven osteitis in patients with rheumatoid arthritis2012

    • Author(s)
      川尻 真也
    • Organizer
      EULAR2012
    • Place of Presentation
      ドイツベルリン
    • Related Report
      2013 Final Research Report
  • [Presentation] Automated Breast Volume Scanner (ABVS), a new automated ultrasonic device, is useful to examine joint injury in patients with rheumatoid arthritis2012

    • Author(s)
      川尻 真也
    • Organizer
      ACR2012
    • Place of Presentation
      アメリカワシントンD.C.
    • Related Report
      2013 Final Research Report
  • [Presentation] 臨床的寛解に到達した関節リウマチ患者における関節エコー所見の検討.2012

    • Author(s)
      川尻 真也, 西野 文子, 鈴木 貴久, 中島 好一, 寶來 吉朗, 岡田 覚丈, 一瀬 邦弘, 玉井 慎美, 中村 英樹, 折口 智樹, 江口 勝美, 川上 純.
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 関節エコーは2010年分類基準の早期関節リウマチにおける診断能を向上させる.2012

    • Author(s)
      川尻 真也, 西野 文子, 鈴木 貴久, 中島 好一, 寶來 吉朗, 岡田 覚丈, 一瀬 邦弘, 玉井 慎美, 山崎 聡士, 中村 英樹, 折口 智樹, 青柳 潔, 上谷 雅孝, 江口 勝美, 川上 純.
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Musculoskeletal ultrasonography assists the diagnostic performance of 2010 rheumatoid arthritis criteria.2012

    • Author(s)
      川尻真也、西野文子、鈴木貴久、中島好一、寶來吉朗、岡田覚丈、一瀬 邦弘、玉井慎美、山崎聡士、中村英樹、 折口智樹、青柳潔、上谷雅孝、江口勝美、川上純
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 関節エコーは2010年分類基準の早期関節リウマチにおける診断能を向上させる.2012

    • Author(s)
      川尻真也、西野文子、鈴木貴久、玉井慎美、中村英樹、折口智樹、川上 純
    • Organizer
      第110回日本内科学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Power Doppler assessment of synovial vascularity predicts the presence of magnetic resonance imaging-proven osteitis in patients with rheumatoid arthritis.2012

    • Author(s)
      Shin-ya Kawashiri, Takahisa Suzuki, Okada, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Atsushi Kawakami.
    • Organizer
      欧州リウマチ学会
    • Place of Presentation
      ドイツ、ベルリン
    • Related Report
      2012 Research-status Report
  • [Presentation] 臨床的寛解持続関節リウマチ患者における関節エコー所見の検討2012

    • Author(s)
      川尻真也、鈴木貴久、中島好一、寶來吉朗、岡田覚丈、一瀬邦弘、玉井慎美、中村英樹、折口智樹、川上純
    • Organizer
      第33回日本炎症再生医学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] CUSON S2000 ABVS (Automated Breast Volume Scanner)を用いた関節リウマチ患者における手指関節自動スキャンの検討2012

    • Author(s)
      川尻真也、鈴木貴久、中島好一、寶來吉朗、岡田覚丈、岩本直樹、一瀬邦弘、玉井慎美、有馬和彦、中村英樹、折口智樹、青柳潔、川上純.
    • Organizer
      第44回九州リウマチ学会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report
  • [Presentation] Automated Breast Volume Scanner (ABVS), a new automated ultrasonic device, is useful to examine joint injury in patients with rheumatoid arthritis.2012

    • Author(s)
      Shin-ya Kawashiri, Takahisa Suzuki, Okada, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Atsushi Kawakami.
    • Organizer
      米国リウマチ学会
    • Place of Presentation
      ワシントンD.C.
    • Related Report
      2012 Research-status Report
  • [Presentation] Severe joint injury assessed by musculoskeletal ultrasonography (MSKUS) predicts the presence of MRI-proven osteitis in patients with rheumatoid arthritis.2012

    • Author(s)
      Shin-ya Kawashiri, Takahisa Suzuki, Okada, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Atsushi Kawakami.
    • Organizer
      米国リウマチ学会
    • Place of Presentation
      ワシントンD.C.
    • Related Report
      2012 Research-status Report
  • [Presentation] ACUSON S2000 ABVS (Automated Breast Volume Scanner)を用いた関節リウマチ患者における手指関節自動スキャンの検討2012

    • Author(s)
      川尻真也、鈴木貴久、中島好一、寶來吉朗、岡田覚丈、岩本直樹、一瀬邦弘、玉井慎美、有馬和彦、中村英樹、折口智樹、青柳潔、川上純
    • Organizer
      第27回日本臨床リウマチ会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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